Implant placement is an important
repair method in dentistry and
orthopedics. Increasing efforts have focused on optimizing the biocompatibility
and osseointegration properties of titanium (Ti) and Ti-based alloys.
In this work, Ti-based alloys were modified by the layer-by-layer
(LbL) technique, which is a simple and versatile method for surface
modification. The morphology and chemical structure of LbL films of
poly(sodium 4-styrenesulfonate) (PSS) and Ti dioxide (TiO2) nanoparticles were first characterized employing ultraviolet–visible
and Fourier-transform infrared spectroscopies as well as atomic force
microscopy for further application in Ti-based alloy implants. The
changes provoked by the LbL PSS/TiO2 film on the Ti-based
alloy surfaces were then investigated by scanning electron microscopy
and micro-Raman techniques. Finally, in vivo tests (immunolabeling
and biomechanical analysis) performed with screw implants in rats
suggested that PSS/TiO2 multilayers promote changes in
both topography and chemical surface properties of the screw, providing
beneficial effects for osteoblast activity. This simple and relatively
low-cost growth process can open up possibilities to improve dental
implants and, probably, bone implants in general.