A novel temperature and <scp>pH</scp> dual‐responsive hybrid hydrogel with polyhedral oligomeric silsesquioxane as crosslinker: synthesis, characterization and drug release properties

Zhang, Xiaojing; Li, Chong; Hu, Yuelei; Liu, Ruixue; He, Linghao; Fang, Shaoming

doi:10.1002/pi.4757

Cited by 29 publications

(16 citation statements)

References 46 publications

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“…For the sample containing MA‐POSS, the cumulative release rate is lower than the others at the initiating stage. The reason is that the unique spatial structure of MA‐POSS is favorable to the storage and slow release of drugs . The SEM results show that the polymer network structure is dense and limits drug loading and release.…”

Section: Resultsmentioning

confidence: 99%

Preparation and performance of thermosensitive poly(N‐isopropylacrylamide) hydrogels by frontal photopolymerization

Yang²,

Chen³

et al. 2019

Polymer International

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In this study, frontal photopolymerization was applied to the fabrication of thermosensitive poly(N‐isopropylacrylamide) (PNIPAm) hydrogels. The influence of experimental conditions and reactant components on the feature of the polymerization front was investigated. The morphology of the samples indicated the successful preparation of PNIPAm hydrogels. The mechanical properties and thermal stability of the obtained hydrogels are discussed. The results indicated that the performance of the hydrogels is related to their microstructure and the type of crosslinkers. The swelling behavior and drug delivery ability were determined under different temperature conditions. The hydrogels exhibit a classical thermoresponsive behavior, which was also demonstrated by the DSC results. Therefore, frontal photopolymerization can be an alternative method for the preparation of PNIPAm hydrogels under mild conditions. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Preparation and performance of thermosensitive poly(N‐isopropylacrylamide) hydrogels by frontal photopolymerization

Yang²,

Chen³

et al. 2019

Polymer International

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“…[41][42][43] Furthermore, organic-inorganic hydrogels containing POSS have also attracted much interest. 45 It is shown that the incorporation of OVPS has improved the mechanical and swelling properties of the hybrid hydrogel. The hybrid hydrogels displayed much faster response rates than conventional hydrogels made by N, N 0 -methylene bisacrylamide (BIS).…”

Section: Introductionmentioning

confidence: 99%

Enhanced mechanical properties and self‐healing behavior of PNIPAM nanocomposite hydrogel by using POSS as a physical crosslinker

Zhang

Shen

Dou

et al. 2019

J of Applied Polymer Sci

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In this study, water-soluble octa(3-chloroammoniumpropyl) silsesquioxane (OCAPS) was found to aggregate into nanoparticles with a positive charge in solution, which can attract persulfate anion radical to initiate N-isopropylacrylamide monomers. Due to the electrostatic and hydrogen bond interaction between OCAPS and poly(N-isopropylacrylamide) (PNIPAM) chain, OCAPS can act as an effective physical crosslinker to result in a nanocomposite hydrogel (OCAPS-PNIPAM) with very small loading N, N 0 -methylene-bisacrylamide (50-100 ppm). The incorporation of OCAPS increases the crosslinking degree of the PNIPAM hydrogel and decreases the swelling ratio in deionized water. The mechanical properties of OCAPS-PNIPAM hydrogel were enhanced greatly by the presence of OCAPS and can be adjusted by the feed ratio. The compression and elasticity moduli vary from 3.52 to 7.59 kPa and 7.67 to 33.91 kPa, respectively. The tensile strength ranges from 6.82 to 243.41 kPa with fracture energy between 503.5 and 4781.7 JÁm −2 . Rheological measurements suggest that OCAPS-PNIPAM hydrogels have stable networks and the loss factor decreases as increasing OCAPS content. OCAPS-PNIPAM hydrogels also can self-heal under certain conditions with low crosslinker loading.

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“…In yet another interesting work, Zhang et al . synthesized a novel temperature and pH dual‐responsive hybrid hydrogel with octavinyl POSS as the crosslinker, and the synthesized hydrogel was utilized for the delivery of norfloxacin …”

Section: Introductionmentioning

confidence: 99%

Synthesis of polyhedral oligomeric silsesquioxane nano‐crosslinked poly(ethylene glycol)‐based hybrid hydrogels for drug delivery and antibacterial activity

Arsalani

Kazeminava

Akbari

et al. 2018

Polymer International

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The synthesis is reported of novel hybrid hydrogels based on ethylenediaminetetraacetic acid dianhydride and poly(ethylene glycol) (PEG) with octa‐aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt (OA‐POSS) as a nano‐crosslinker under solvent‐free conditions. The molecular weight of PEG was varied between 600 and 1000 Da. The synthesized hydrogels were characterized using various techniques. Further, the swelling behavior and antibacterial activity of the hydrogels and release kinetics of metronidazole (MTZ) as a model drug from them were evaluated. Experimental results demonstrate that hydrogels with tunable properties can be synthesized by varying the PEG molecular weight and type of crosslinker (hybrid or organic). Among the synthesized hybrid hydrogels, that crosslinked by OA‐POSS with long PEG chains (1000 Da) showed the highest swelling degree (2000%), drug encapsulation efficiency (88%) and extent of MTZ release (96%). © 2018 Society of Chemical Industry

show abstract

A novel temperature and pH dual‐responsive hybrid hydrogel with polyhedral oligomeric silsesquioxane as crosslinker: synthesis, characterization and drug release properties

Cited by 29 publications

References 46 publications

Preparation and performance of thermosensitive poly(N‐isopropylacrylamide) hydrogels by frontal photopolymerization

Preparation and performance of thermosensitive poly(N‐isopropylacrylamide) hydrogels by frontal photopolymerization

Enhanced mechanical properties and self‐healing behavior of PNIPAM nanocomposite hydrogel by using POSS as a physical crosslinker

Synthesis of polyhedral oligomeric silsesquioxane nano‐crosslinked poly(ethylene glycol)‐based hybrid hydrogels for drug delivery and antibacterial activity

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