A novel theranostic nanoplatform for imaging-guided chemo-photothermal therapy in oral squamous cell carcinoma

Gu, Mengqin; Li, Jiang; Hao, Liang; Lu, Jiating; Liu, Zhenqi; Lei, Zhouyue; Li, Yijun; Hua, Chengge; Li, Wei; Li, Xiyu

doi:10.1039/d1tb01136g

Cited by 19 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although Doxo is not considered the gold standard for chemotherapy in OSCC, some studies have been reported the use of Doxo for noninvasive diagnostic imaging and therapeutical application using multifunctional nanotechnology to increase the intracellular uptake [ 13 , 14 ]. In tumor advancement, proto-oncogenes such as c-Myc and Bcl-2 are considered as genes that regulate cellular proliferation and apoptosis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression

et al. 2022

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) represents 90% of malignant epithelial cancer that occurs in the oral cavity. The c-Myc factor is expressed in multiple types of cancer, comprising head and neck squamous cell carcinoma (HNSCC), where it plays a fundamental role in tumor prognosis and in the self-renewal of tumor stem cells. However, the role of c-Myc in controlling OSCC cells is not well-known. The aim of the present study is the evaluation of the biological roles and regulatory mechanism of c-Myc in the pathogenesis of OSCC. Results indicated that c-Myc, c-Jun, Bcl-2, hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), ERK 1/2 and pERK1/2 were overexpressed in a cellular model of squamous cell carcinoma, Cal-27. Doxorubicin (Doxo), a common chemotherapeutic agent, inhibited cell invasion, hypoxia, angiogenesis and inflammation in a cellular model of Cal-27 cells as indicated by downregulation of MMP-9, VEGF, ERK 1/2 and pERK 1/2 as well as promoted apoptosis as evidenced by the downregulation of Bcl-2 protein. This work aimed at underlying the functional relevance of c-Myc in OSCC and the HIF-Myc collaboration by integrating the knowledge on this molecular link in an OSCC tumor microenvironment. The results obtained showed for the first time the vital role of c-Myc in Cal-27 in cell survival/proliferation and tumor growth as well as the negative regulatory effect of Doxo against c-Myc signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In addition, Gu et al reported that terbium ion-doped hydroxyapatite (HATb) nanoparticles can be used as luminescent probes to encapsulate the NIR photothermal agent PDA and DOX for imaging guided synergistic therapy of chemotherapy and PTT [ 3 ]. Xu et al successfully prepared a new nanosystem for OSCC using HA and hollow mesoporous Prussian blue nanoparticles, which were loaded with DOX (HMPBs&DOX@HAMNs).…”

Section: Organic Nanoparticlesmentioning

confidence: 99%

“…For centuries, cancer has been one of the most devastating diseases worldwide [ 1 ]. Oral squamous cell carcinoma (OSCC) is associated with high morbidity, high malignancy, and poor prognosis, and has been one of the top 15 most prevalent cancers worldwide [ 2 , 3 ]. However, the current main treatment methods for OSCC (e.g., surgery, chemotherapy, radiotherapy, and combination therapy) have some disadvantages [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma

Qin

Sun

Bai

et al. 2022

IJMS

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is one of the top 15 most prevalent cancers worldwide. However, the current treatment models for OSCC (e.g., surgery, chemotherapy, radiotherapy, and combination therapy) present several limitations: damage to adjacent healthy tissue, possible recurrence, low efficiency, and severe side effects. In this context, nanomaterial-based photothermal therapy (PTT) has attracted extensive research attention. This paper reviews the latest progress in the application of biological nanomaterials for PTT in OSCC. We divide photothermal nanomaterials into four categories (noble metal nanomaterials, carbon-based nanomaterials, metal compounds, and organic nanomaterials) and introduce each category in detail. We also mention in detail the drug delivery systems for PTT of OSCC and briefly summarize the applications of hydrogels, liposomes, and micelles. Finally, we note the challenges faced by the clinical application of PTT nanomaterials and the possibility of further improvement, providing direction for the future research of PTT in OSCC treatment.

show abstract

“…Oral squamous cell carcinoma (OSCC), which mostly happens in the tissues of the tongues or lips, is one of the most common oral malignancies. 1,2 Nowadays, surgical resection is the primary therapeutic strategy for OSCC. 3,4 However, surgery is highly dependent on the medical diagnosis and lesion size, and this aggressively invasive treatment has inevitable sequelae, resulting in facial deformities and severe oral physiological dysfunction such as impaired linguistic and food-intake capabilities.…”

Section: Introductionmentioning

confidence: 99%

“…Oral squamous cell carcinoma (OSCC), which mostly happens in the tissues of the tongues or lips, is one of the most common oral malignancies. , Nowadays, surgical resection is the primary therapeutic strategy for OSCC. , However, surgery is highly dependent on the medical diagnosis and lesion size, and this aggressively invasive treatment has inevitable sequelae, resulting in facial deformities and severe oral physiological dysfunction such as impaired linguistic and food-intake capabilities. , Therefore, some noninvasive treatments such as radiotherapy, photothermal therapy, and sonodynamic therapy have emerged in the therapeutic strategies of oral cancer. − Radiotherapy is the primary noninvasive treatment in clinics for OSCC with less impact on the appearance and oral function, which relies on the mechanism of reactive oxygen species (ROS) generation from water radiolysis. − Nevertheless, radiotherapy also has nonnegligible limitations. On the one hand, OSCC is a locally aggressive tumor characterized by massive tumor necrosis and local hypoxia, leading to low radiosensitivity. , On the other hand, radiation sequelae that hinder patients’ tolerance to high-dose radiotherapy are also an important factor limiting the course of radiotherapy, such as high-incidence radiation-induced oral mucositis and xerostomia (salivary gland injury) after head and neck radiotherapy. − Therefore, it is of great significance to develop a highly efficient and low-toxic radiosensitization strategy for improving the therapeutic outcome and reducing the side effects during treatment.…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Tantalum Nanocomposite Hydrogels for In Situ Oral Cancer Treatment

Zhao

Dai

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is one of the most common oral malignancies. Radiotherapy is the primary noninvasive treatment of OSCC for avoiding surgery-induced facial deformities and impaired oral function. However, the specificity of in situ OSCC limits radiotherapeutic effects because of the hypoxia-induced low radiosensitivity of tumors and the low radiation tolerance of surrounding normal tissues. Here, we design a highly efficient and low-toxic radiosensitization strategy. On the one hand, biocompatible poly(vinyl pyrrolidone)-modified tantalum nanoparticles (Ta@PVP NPs) not only have strong X-ray deposition capability to upregulate oxidative stress but also have photothermal conversion efficiency to improve hypoxia for tumor radiosensitivity. On the other hand, to optimize the spatial distribution of Ta@PVP NPs within tumors, mussel-inspired catechol with bioadhesive properties is grafted on tumor microenvironment-responsive sodium alginate (DAA) to form in situ hydrogels for precision radiotherapy. On this basis, we find that Ta@PVP-DAA hydrogels effectively inhibit OSCC development in mice under photothermal-assisted radiotherapy without facial deformities and damage to surrounding normal tissues. Overall, our work not only promotes the exploration of Ta@PVP NPs as new radiosensitizers for OSCC but also develops a nanocomposite hydrogel system strategy as a promising paradigm for the precision treatment of orthotopic tumors.

show abstract

A novel theranostic nanoplatform for imaging-guided chemo-photothermal therapy in oral squamous cell carcinoma

Abstract: Oral squamous cell carcinoma (OSCC) is highly malignant and invasive, and current treatments are limited due to serious side effects and unsatisfactory outcomes. Here, we reported the terbium ions-doped hydroxyapatite...

Cited by 19 publications

References 31 publications

C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression

C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression

Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma

Mussel-Inspired Tantalum Nanocomposite Hydrogels for In Situ Oral Cancer Treatment

Contact Info

Product

Resources

About