A novel therapeutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporine: Results of a multicenter placebo-controlled study

Grossman, Rachel; Thivolet, J; Claudy, A; Souteyrand, P; Guilhou, J J; Thomas, Philip; Amblard, P; Belaïch, S; Bélilovsky, C. de; Brassinne, M de la; Martinet, C; Bazex, J; Beylot, C; Combemale, P.; Lambert, D; Ostojić, Alen; Denoeux, J. P.; Lauret, P; Vaillant, L.; Weber, Michael A.; Pamphile, Raymond; Dubertret, Louis

doi:10.1016/s0190-9622(94)70138-5

Cited by 122 publications

(65 citation statements)

References 16 publications

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“…Additionally, calcipotriol ointment has also been used in combination with PUVA [14], cyclosporin [15], acitretin [16], various topical corticosteroids [17]and UVB radiation [18, 19, 20, 21, 22, 23]for treatment of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Calcipotriol Cream Combined with Twice Weekly Broad-Band UVB Phototherapy: A Safe, Effective and UVB-Sparing Antipsoriatric Combination Treatment

Ramsay

Schwartz²,

Lowson

et al. 2000

Dermatology

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Background: Calcipotriol has been combined with a number of systemic antipsoriatric treatments, improving efficacy or reducing the systemic treatment required. Although studies on calcipotriol and UVB have also been performed, there are no data on the UVB-saving effect of calcipotriol combined with broad-band UVB to reduce overall UVB exposure, while maintaining efficacy. Objectives: To assess the efficacy and safety of calcipotriol cream (50 μg/g) combined with twice weekly broad-band UVB and to determine if this treatment would require fewer UVB treatments and lower cumulative UVB irradiance when compared to a standard 3 times weekly broad-band UVB regime in patients with extensive psoriasis. Methods: This multicentre, prospective, randomised, parallel-group, vehicle-controlled, single-blind (investigator) study consisted of a 1-week wash-out phase, 12-week treatment phase and 12-week follow-up phase. Broad-band UVB equipment was standardised and calibrated prior to the study. The UVB starting dose was based on the patient’s minimal erythema dose. Assessments included PASI, extent, severity and investigator and patient’s overall assessments of the psoriasis. Results: Fewer exposures (12 vs. 19) and less cumulative UVB irradiance (1,570 vs. 5,430 mJ/cm²) were required by the calcipotriol + twice weekly UVB group to achieve 80% reduction in PASI (p < 0.001). Similarly, fewer exposures (22 vs. 25) and less cumulative UVB irradiance (4,147 vs. 9,670 mJ/cm²) were required by this group to achieve total clearance (p < 0.001). There was no difference in the PASI, patient’s and investigator’s overall assessments and number of adverse events recorded by either group for both the treatment and follow-up phases. Conclusion: Calcipotriol cream + twice weekly broad-band UVB phototherapy is an effective and safe antipsoriatric treatment, resulting in fewer UVB exposures, lower cumulative irradiance and a saving of time.

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Section: Introductionmentioning

confidence: 99%

Calcipotriol Cream Combined with Twice Weekly Broad-Band UVB Phototherapy: A Safe, Effective and UVB-Sparing Antipsoriatric Combination Treatment

Ramsay

Schwartz²,

Lowson

et al. 2000

Dermatology

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“…In 13 patients with severe persistent psoriasis, cyclosporin 1-4 mg/kg/day was administered for 12-25 months, and an 81% decrease was noted in mean PASI score; 85% of the patients had received topical corticosteroid therapy after the first 3 months of cyclosporin (Griffiths et al, 1989). A larger randomised, double-blind, placebo-controlled trial in 69 cyclosporin-treated (2 mg/kg/day) patients with severe chronic plaque psoriasis revealed clinical improvement in a significantly greater proportion of patients who used concomitant calcipotriol 50 µg/g ointment versus vehicle: 50% vs 12% of patients (p=0.0019) had complete clearing of psoriasis or a ≥90% improvement in PASI score (Grossman et al, 1994).…”

Section: Topical Treatmentsmentioning

confidence: 99%

Systemic Cyclosporin in the Treatment of Psoriasis

Colombo¹,

Pietro²

2012

Psoriasis

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“…One trial 18 compared calcipotriene and cyclosporine with placebo ointment and cyclosporine in 69 patients. The calcipotriene and cyclosporine combination was significantly more effective than placebo and cyclosporine on the basis of the proportion of patients cleared and the percentage change in PASI.…”

Section: Calcipotriene and Cyclosporinementioning

confidence: 99%

Combination Regimens of Topical Calcipotriene in Chronic Plaque Psoriasis

Ashcroft

Po²,

Williams³

et al. 2000

Arch Dermatol

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To examine the efficacy and tolerability of calcipotriene combined with phototherapy or systemic therapies compared with monotherapy for the treatment of chronic plaque psoriasis.Design: Quantitative systematic review of 11 randomized controlled trials involving a total of 756 patients with plaque psoriasis.Main Outcome Measures: Rate ratios (RRs) for marked improvement or clearance in patient and investigator overall assessments of response; mean difference in percentage change in Psoriasis Area and Severity Index; and RRs for clearance in patient and investigator overall assessments of response. Adverse effects were estimated with the RR and the rate difference in terms of withdrawal rate, proportion of patients experiencing adverse events, and proportion of patients with cutaneous and noncutaneous adverse effects.Results: Antipsoriatic effects of acitretin, cyclosporine, and psoralen-UV-A phototherapy were enhanced with the addition of topical calcipotriene using the Psoriasis Area and Severity Index as the outcome, but this is not translated into an increase in the number of patients who achieve at least marked improvement. At the end of treatment, the RRs for marked improvement or clearance in patient assessments were as follows: calcipotriene plus acitretin vs acitretin alone (12 weeks), 1.4 (95% confidence interval [CI], 1.0-1.9); calcipotriene plus cyclo-

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A novel therapeutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporine: Results of a multicenter placebo-controlled study

Cited by 122 publications

References 16 publications

Calcipotriol Cream Combined with Twice Weekly Broad-Band UVB Phototherapy: A Safe, Effective and UVB-Sparing Antipsoriatric Combination Treatment

Calcipotriol Cream Combined with Twice Weekly Broad-Band UVB Phototherapy: A Safe, Effective and UVB-Sparing Antipsoriatric Combination Treatment

Systemic Cyclosporin in the Treatment of Psoriasis

Combination Regimens of Topical Calcipotriene in Chronic Plaque Psoriasis

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