A novel titania/calcium silicate hydrate hierarchical coating on titanium

Huang, Qianli; Liu, Xujie; Elkhooly, Tarek A.; Zhang, Ranran; Shen, Zhijian; Feng, Qingling

doi:10.1016/j.colsurfb.2015.07.002

Cited by 43 publications

(20 citation statements)

References 57 publications

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“…29 Thus, Huang et al demonstrated that hierarchical surface enhances fibronectin absorption and initial MG-63 cell attachment. 30 Up-do-date reported studies indicate that in the hierarchical coatings the microtopography influences the initial cell attachment, while the nanosurface induces the biochemical intracellular changes that lead to cell proliferation and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Improved osseointegration properties of hierarchical microtopographic/nanotopographic coatings fabricated on titanium implants

Zemtsova¹,

Yudintceva²,

Morozov³

et al. 2018

IJN

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BackgroundTitanium (Ti) implants are extensively used in reconstructive surgery and orthopedics. However, the intrinsic inertness of untreated Ti implants usually results in insufficient osseointegration. In order to improve the osteoconductivity properties of the implants, they are coated with hierarchical microtopographic/nanotopographic coatings employing the method of molecular layering of atomic layer deposition (ML-ALD).ResultsThe analysis of the fabricated nanostructured relief employing scanning electron microscopy, atomic force microscopy, and electron spectroscopy for chemical analysis clearly demonstrated the formation of the nanotopographic (<100 nm) and microtopographic (0.1–0.5 μm) titano-organic structures on the surface of the nanograined Ti implants. Subsequent coincubation of the MC3T3-E1 mouse osteoblasts on the microtopographic/nanotopographic surface of the implants resulted in enhanced osteogenic cell differentiation (the production of alkaline phosphatase, osteopontin, and osteocalcin). In vivo assessment of the osseointegrative properties of the microtopographically/nanotopographically coated implants in a model of below-knee amputation in New Zealand rabbits demonstrated enhanced new bone formation in the zone of the bone–implant contact (as measured by X-ray study) and increased osseointegration strength (removal torque measurements).ConclusionThe fabrication of the hierarchical microtopographic/nanotopographic coatings on the nanograined Ti implants significantly improves the osseointegrative properties of the intraosseous Ti implants. This effect could be employed in both translational and clinical studies in orthopedic and reconstructive surgery.

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Section: Introductionmentioning

confidence: 99%

Improved osseointegration properties of hierarchical microtopographic/nanotopographic coatings fabricated on titanium implants

Zemtsova¹,

Yudintceva²,

Morozov³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…Multitudinous studies have conrmed the potential of calcium to upregulate the bone-related genes expressions and elicit satisfactory biological effects. 1,[21][22][23][24] Moreover, other titanium surface properties, including microscale topography, nanostructures, and chemical composition, could inuence the osteoblast behavior. [44][45][46] Considering the abovementioned factors, we believe that calcium incorporated into the nanosheets might contribute to enhance the bioactivity of the modied titanium surfaces in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…21 Several studies have demonstrated that a Ca-rich layer on the titanium surface has the ability to accelerate the osseointegration process at both cellular and histological levels. [22][23][24] To date, various modication techniques, including plasma spraying, 25,26 physical vapor deposition, 27,28 chemical treatments, 9,29 anodic oxidation, 30,31 micro-arc oxidation, 22 and calcium plasma immersion ion implantation, have been developed to prepare micro/nanostructures-modied or calcium-containing titanium surfaces. 1,23 However, it is difficult to form micro/ nanostructures and directly incorporate calcium onto the titanium surface during an identical modication process.…”

Section: Introductionmentioning

confidence: 99%

Modification of a SLA titanium surface with calcium-containing nanosheets and its effects on osteoblast behavior

et al. 2017

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“…However, the osteogenic capacity of bone cells on this macro/mesoporous structure was not investigated. In several reports, hierarchical structures have been shown to exhibit synergistic effects on the enhancement of osteogenic activity when compared with solo topography . Therefore, we assume that modification of the Ti‐based alloy surface with macro/mesoporous structures would be beneficial for osseointegration.…”

Section: Introductionmentioning

confidence: 98%

Effects of the hierarchical macro/mesoporous structure on the osteoblast‐like cell response

Zhang

Elkhooly

Huang

et al. 2018

J Biomedical Materials Res

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To improve the success of medical devices, implants with strong surface bioactivity are urgently required. Coatings with a macroporous structure produced by micro-arc oxidation possess advantages, such as strong adhesion to substrate and excellent resistance to wear and corrosion. Mesoporous structures contain pores with sizes of 2-50 nm, which can endow the biomaterials with the ability to enhance osteogenesis and to be loaded with diverse drugs. Thus, in this study, we aimed to evaluate the effects of both macroporous and mesoporous structures using a hierarchical macro/mesoporous structure to modify the titanium implant surface. The behaviors of SaOS-2 human osteosarcoma cells on the macro/mesoporous structure, including initial adhesion, proliferation, alkaline phosphatase (ALP) activity, and collagen secretion, were investigated. Cells that attached on the macro/mesoporous surface showed the highest cell numbers and greatest spreading area after incubation for 1, 2, and 4 h compared with the polished smooth substrate and macroporous surface in the presence of fetal bovine serum (FBS). However, in the absence of FBS, cell adhesion on the polished substrate, macroporous structure, and macro/mesoporous structure did not differ significantly. Cell proliferation on the macroporous and macro/mesoporous surfaces increased compared with that on the smooth substrate surface. Furthermore, ALP activity and collagen secretion were enhanced on the macro/mesoporous structure. Our findings provided important insights into the cellular responses to macro/mesoporous structures in the field of implant surface modification. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1896-1902, 2018.

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A novel titania/calcium silicate hydrate hierarchical coating on titanium

Cited by 43 publications

References 57 publications

Improved osseointegration properties of hierarchical microtopographic/nanotopographic coatings fabricated on titanium implants

Improved osseointegration properties of hierarchical microtopographic/nanotopographic coatings fabricated on titanium implants

Modification of a SLA titanium surface with calcium-containing nanosheets and its effects on osteoblast behavior

Effects of the hierarchical macro/mesoporous structure on the osteoblast‐like cell response

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