“…More importantly, family screening should be advised, as for our patient whose sister was also consequently diagnosed with MVP. A familial distribution of MVP has been largely documented especially in Barlow's patients [16,17] and four genes are known so far to be linked to MVP; interestingly, also an association of isolated MVP and mutations in cardiomyopathy genes was observed, further supporting the important role of myocardial involvement in the disease [18,19]. Finally, the possibility of testing specific biomarkers might be offered in the future; for example, initial observations showed the soluble suppression of tumourigenicity-2-serum level (sST2), as a marker of the stretched myocardium, to be higher in patients with mitral annular disjunction and VA [20].…”