Abstract.The thermister based temperature measurement scheme is widely applied for its low cost, strong stability and well flexibility. As the property between resistance and temperature is nonlinear, the practical application of thermister usually relies on the method of table look-up. Inevitably, that leads to the problems of poor versatility and large memory cost. Based on the analyses of resistance and temperature property, we propose an optimal linearization method of parameter design for NTC thermister interface circuit in this paper. The proposed approach is simple, but has a good linearity and high sensitivity. Test results are given to support the theoretical analyses and conclusions.