A novel Y-Z magnetic totally implantable venous access port based on the magnetic anchor technique

Abstract

A totally implantable venous access port (TIVAP) is a commonly used intravenous infusion device for patients receiving chemotherapy or long-term infusion therapy. To improve the success rate of one-time insertion of the Huber needle, we developed a novel Y-Z magnetic TIVAP (Y-Z MTIVAP), which we produced using three-dimensional printing technology. The Y-Z MTIVAP includes a magnetic port body and a magnetic positioning device. For testing, we established four venous port implantation models using the two types of TIVAPs and two implantation depth ranges (≤ 5 mm and > 5 mm). Twenty nurses performed Huber needle puncture with the four models, and we recorded the number of attempts required for successful needle insertion, the operation time, and the operator’s satisfaction. The success rate for one-time needle insertion with the Y-Z MTIVAP was significantly higher than that with the traditional TIVAP at either depth range (100% vs 75% at ≤ 5 mm, p = 0.047; 95% vs 35% at > 5 mm, p < 0.001). With increasing implantation depth, the success rate for one-time insertion was significantly reduced with the traditional TIVAP (75% at ≤ 5 mm vs 35% vs > 5 mm, p = 0.025), but the success rate with the Y-Z MTIVAP was not significantly affected (100% vs 98%, p = 1.000). The operation time with the Y-Z MTIVAP was significantly shorter than that with the traditional TIVAP at either depth range (both p < 0.001), and 90% of operators reported that the Y-Z MTIVAP was superior to the traditional TIVAP. In conclusion, Y-Z MTIVAP was associated with a significantly improved puncture success rate and shortened operation time, and thus, has important clinical application value.

In vitro and in vivo study of magnesium containing bioactive glass nanoparticles modified gelatin scaffolds for bone repair

“…The synthesis procedure of bioactive glass ceramic containing magnesium by sol-gel method was reported in previous studies [23,24]. The magnesium bioactive glass nanospheres with composition of SiO 2 -CaO-MgO (80% SiO 2 , 10% CaO, 10% MgO, mol%) were synthesized by sol-gel method, and the particles had spherical morphology with mean particle size of 100-200 nm (figures 2 and 3).…”

Role of hydrogen peroxide receptors in endocarp browning of postharvest longan fruit

“…Total RNA was isolated using the FastPure Plant Total RNA Isolation Kit (Vazyme) to serve as the template for the subsequent first-strand cDNA synthesis, which was finished using the PerfectStart Uni RT & qPCR Kit (TransGen). Three biological replicates were prepared for the quantitative real-time PCR (qRT-PCR) analysis using the Roche LightCycler 480 instrument and the PerfectStart Green qPCR Super-Mix (TransGen) as previously described by Zhang et al (2020Zhang et al ( , 2023.…”

Drug resistance mechanism and reversal strategy in lung cancer immunotherapy

“…Glutamine, a functional substance in metabolites, produces ammonia during catabolism, which activates autophagy in immune cells (Keulers et al, 2022;Ma et al, 2022); arginine was discovered to be degraded in the tumor microenvironment by arginase, which is expressed by immunosuppressive cells such as epithelial M2 macrophages and Tregs, leading to T-cell function inhibition (Lemos et al, 2019;Azambuja et al, 2020). Elevated levels of extracellular adenosine, depletion of tryptophan, and dysregulated activation of the PI3K/ Akt pathway may lead to the development of immune tolerance within the tumor microenvironment, hence diminishing the sensitivity and efficacy of immunotherapy interventions (Lemos et al, 2019;Giannone et al, 2020;Wang et al, 2020).…”