A Parallelogram Approach for Safety Evaluation of Ingested Acetaldehyde

Morris, John B.; Robinson, Denise E.; Vollmuth, Thomas A.; Brown, Ronald P.; Domeyer, Bruce E.

doi:10.1006/rtph.1996.0138

Cited by 14 publications

(5 citation statements)

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“…From these data a total acetaldehyde exposure of 48–96 mg/day (0.64–1.28 mg/kg bodyweight (bw)/day) can be extrapolated (see also [14]). The US Flavor and Extract Manufacturers Association (FEMA) has estimated the possible average daily intake as 35 mg (0.47 mg/kg bw/day) [53] while Morris et al [54] estimated a range of 40–80 mg (0.53–1.07 mg/kg bw/day), with worst case levels up to 200 mg (2.67 mg/kg bw/day) [55]. …”

Section: Resultsmentioning

confidence: 99%

Quantitative Determination of Acetaldehyde in Foods Using Automated Digestion with Simulated Gastric Fluid Followed by Headspace Gas Chromatography

Uebelacker

Lachenmeier

2011

Journal of Automated Methods and Management in Chemistry

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Acetaldehyde (ethanal) is a genotoxic carcinogen, which may occur naturally or as an added flavour in foods. We have developed an efficient method to analyze the compound in a wide variety of food matrices. The analysis is conducted using headspace (HS) gas chromatography (GC) with flame ionization detector. Using a robot autosampler, the samples are digested in full automation with simulated gastric fluid (1 h at 37°C) under shaking, which frees acetaldehyde loosely bound to matrix compounds. Afterwards, an aliquot of the HS is injected into the GC system. Standard addition was applied for quantification to compensate for matrix effects. The precision of the method was sufficient (<3% coefficient of variation). The limit of detection was 0.01 mg/L and the limit of quantification was 0.04 mg/L. 140 authentic samples were analyzed. The acetaldehyde content in apples was 0.97 ± 0.80 mg/kg, orange juice contained 3.86 ± 2.88 mg/kg. The highest concentration was determined in a yoghurt (17 mg/kg). A first-exposure estimation resulted in a daily acetaldehyde intake of less than 0.1 mg/kg bodyweight from food, which is considerably lower than the exposures from alcohol consumption or tobacco smoking.

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Section: Resultsmentioning

confidence: 99%

Quantitative Determination of Acetaldehyde in Foods Using Automated Digestion with Simulated Gastric Fluid Followed by Headspace Gas Chromatography

Uebelacker

Lachenmeier

2011

Journal of Automated Methods and Management in Chemistry

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“…Morris et al, 1996); however, these approaches are typically less well developed than those used to evaluate the potential risk of systemic effects. Risk assessment approaches have been developed to evaluate the potential for some adverse local effects occurring following exposure to toxic compounds (e.g.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Toxicity of Metals Released from Implanted Medical Devices

Brown¹,

Fowler²,

Fustinoni³

et al. 2015

Handbook on the Toxicology of Metals

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“…The dose associated with portal-of-entry effects or local effects seen at the site where the toxic compound fi rst contacts the body (i.e., nasal mucosa in an inhalation study) does not typically serve as the basis for route-to-route extrapolations of dose, with some exceptions (e.g., Morris et al ., 1996). The dose associated with portal-of-entry effects or local effects seen at the site where the toxic compound fi rst contacts the body (i.e., nasal mucosa in an inhalation study) does not typically serve as the basis for route-to-route extrapolations of dose, with some exceptions (e.g., Morris et al ., 1996).…”

Section: Route-to-route Extrapolation Of Dosementioning

confidence: 99%

Allowable limits for toxic leachables: practical use of ISO 10993-17 standard * *The recommendations offered in this chapter should not be construed as guidance from the US Food and Drug Administration (FDA). The mention of commercial products, their sources or their use in connection with material reported herein is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services.

Brown

2012

Biocompatibility and Performance of Medical Devices

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A Parallelogram Approach for Safety Evaluation of Ingested Acetaldehyde

Cited by 14 publications

References 0 publications

Quantitative Determination of Acetaldehyde in Foods Using Automated Digestion with Simulated Gastric Fluid Followed by Headspace Gas Chromatography

Quantitative Determination of Acetaldehyde in Foods Using Automated Digestion with Simulated Gastric Fluid Followed by Headspace Gas Chromatography

Toxicity of Metals Released from Implanted Medical Devices

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