In past several decades, vortex-structure interaction generated aerodynamic noise became one of the main concerns in aircraft design. In order to understand the mechanism, the acoustic analogy method combined with the RANS-based nonlinear acoustics solver (NLAS) is investigated. The numerical method is firstly evaluated by the experiment data of the classic rod-airfoil model. Compared with the traditional analogy methods, the RANS/NLAS can capture the nonlinear aerodynamic noise more accurately with lower gird requirements. Then different rod-airfoil configurations were simulated to investigate the aeroacoustic interaction effects. The numerical results are in good agreement with those of the earlier experimental research. It is found that the vortexshedding crash to the airfoil is the main reason for the noise generation which is dependent on the configurations, distance, and flow conditions.