2023
DOI: 10.1002/rcm.9487
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A passive membrane system for on‐line mass spectrometry reagent addition

Abstract: Rationale: Post-separation addition of chemical modifiers in liquid chromatographymass spectrometry is widely used for improving ionization sensitivity and selectivity. This is typically accomplished using a post-column T-junction, which can result in sample dilution and imperfect mixing. We present a passive semi-permeable hollow fiber membrane approach for the addition of chemical modifiers that avoids these issues.Methods: Model compounds were directly infused by flow injection to an electrospray ionization… Show more

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“…Given the marginal improvements over the regular acceptor phase, we elected not to incorporate base enhancement into the quantitative method (described below) due to the challenges this presents to online membrane transport experiments described previously [33]. Future work will evaluate the use of a second membrane probe for the introduction of ionizationenhancing agents [34].…”
Section: Evaluation Of Pdms Permselectivitymentioning
confidence: 99%
“…Given the marginal improvements over the regular acceptor phase, we elected not to incorporate base enhancement into the quantitative method (described below) due to the challenges this presents to online membrane transport experiments described previously [33]. Future work will evaluate the use of a second membrane probe for the introduction of ionizationenhancing agents [34].…”
Section: Evaluation Of Pdms Permselectivitymentioning
confidence: 99%