A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)

Kovalová, Markéta; Baraka, Joseph Peter; Mik, Václav; Jorda, Radek; Luo, Lei; Shao, Hao; Kryštof, Vladimı́r

doi:10.1080/13543776.2023.2195547

Cited by 9 publications

(1 citation statement)

References 67 publications

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“…Perhaps the biggest success in therapeutic targeting of tCDKs is seen in the example of CDK7, with multiple selective inhibitors currently in Phase I/II clinical trials (Kovalová et al, 2023 ; Sava et al, 2020 ). The dual actions of CDK7, which participates in both regulation of transcription and the cell cycle, have made it an important player in tumorigenesis.…”

Section: Cdk S and Diseasementioning

confidence: 99%

Cyclin‐dependent kinases: Masters of the eukaryotic universe

Pluta,

Studniarek,

Murphy

et al. 2023

WIREs RNA

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A family of structurally related cyclin‐dependent protein kinases (CDKs) drives many aspects of eukaryotic cell function. Much of the literature in this area has considered individual members of this family to act primarily either as regulators of the cell cycle, the context in which CDKs were first discovered, or as regulators of transcription. Until recently, CDK7 was the only clear example of a CDK that functions in both processes. However, new data points to several “cell‐cycle” CDKs having important roles in transcription and some “transcriptional” CDKs having cell cycle‐related targets. For example, novel functions in transcription have been demonstrated for the archetypal cell cycle regulator CDK1. The increasing evidence of the overlap between these two CDK types suggests that they might play a critical role in coordinating the two processes. Here we review the canonical functions of cell‐cycle and transcriptional CDKs, and provide an update on how these kinases collaborate to perform important cellular functions. We also provide a brief overview of how dysregulation of CDKs contributes to carcinogenesis, and possible treatment avenues.This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA‐Protein Complexes RNA Processing > 3′ End Processing RNA Processing > Splicing Regulation/Alternative Splicing

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Section: Cdk S and Diseasementioning

confidence: 99%