A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

Duong, Thoa; López‐Iglesias, Clara; Szewczyk, Piotr K.; Stachewicz, Urszula; Barros, Joana; Álvarez-Lorenzo, Carmen; Alnaief, Mohammad; García‐González, Carlos A.

doi:10.3389/fbioe.2021.671381

Cited by 27 publications

(16 citation statements)

References 88 publications

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“…Also, the figure revealed the presence of pores within the aggregates (Figure 8d–f) which is favorable for respiratory delivery of powders. Duong and coworkers reported the importance of porous materials for DPI formulations due to better aerodynamic performance, and provision of Large surface area 32 . ImageJ analysis of 50 aggrates revealed an average particles size of 3.07 ± 1.02 μm.…”

Section: Resultsmentioning

confidence: 99%

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Novel poly(ester amide) derived from tyrosine amino acid for targeted pulmonary drug delivery of fluticasone propionate

AbdulKarim

Ali

Taybeh

et al. 2023

J of Applied Polymer Sci

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Nanoaggregates made from amino acid-based polymers have been an important platform for targeted drug delivery systems such as the lungs. Therefore, the aim of the present study is to develop tyrosine-based poly(ester amide)s (Tyr-PEA) for dry powder inhaler (DPI) of a potent drug (fluticasone propionate [FP]) using interfacial polymerization. The molecular and surface profiling characteristics were evaluated using Fourier-transformed infrared spectroscopy, X-ray diffraction, transmission electron microscopy, particle size analysis, nuclear magnetic resonance, differential scanning calorimetry, and scanning electron micrographs. The aerodynamic performance was evaluated using the NGI. The results confirmed the formation of the PEA and FP-loaded Tyr-PEA with an average particle size of, 45.39 ± 6.32 nm. The produced FP/Tyr-PEA showed entrapment efficiency and encapsulation capacity of FP of 92.32% and 0.526% respectively, which enabled the delivery of this potent drug in a reasonable dose. The in-vitro performance of the FPloaded PEA was compared to a marketed product and results revealed a significant enhancement of the emitted dose (87.29% vs. 59% respectively [t-test, p < 0.05]). FP-loaded Tyr-PEA produced a higher respirable dose when compared to the marketed FP DPI (48.63 μg vs. 34.15 μg). Overall, FP-loaded Tyr-PEA was successfully prepared with optimal performance. Tyr-PEA-based nanoparticles provide a potential platform for targeted drug delivery, particularly potent actives.

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Section: Resultsmentioning

confidence: 99%

“…Duong and coworkers reported the importance of porous materials for DPI formulations due to better aerodynamic performance, and provision of Large surface area. 32 ImageJ analysis of 50 aggrates revealed an average particles size of 3.07 ± 1.02 μm. Such results supports the aerodynamic performance analysis.…”

Section: Sem Analysismentioning

confidence: 99%

Novel poly(ester amide) derived from tyrosine amino acid for targeted pulmonary drug delivery of fluticasone propionate

AbdulKarim

Ali

Taybeh

et al. 2023

J of Applied Polymer Sci

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“…The present COVID-19 epidemic has sparked a resurgence of interest in pulmonary medicine drug carriers and their use in the treatment of respiratory illnesses. For example, according to Duong et al, for the existing COVID-19 condition, aerogel technologies have great potential for resolving pulmonary drug-delivery problems as in Figure 9 [ 195 ].…”

Section: Coronavirus Disease (Covid-19)mentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

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“…During drying, the water enters the organic phase and creates a porous matrix. Recently, SD INBRIJA TM (levodopa) inhalable large porous particles were approved by the EMA and FDA for commercialization as a replacement for dopamine as a fast reaction doubled with rapid growth plasma levodopa concentration for treating Parkinson disease [ 96 , 100 ].…”

Section: Approaches For Particle Engineeringmentioning

confidence: 99%

Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches

Negi,

Nimbkar,

Moses

2023

Pharmaceutics

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Respirable particles are integral to effective inhalable therapeutic ingredient delivery, demanding precise engineering for optimal lung deposition and therapeutic efficacy. This review describes different physicochemical properties and their role in determining the aerodynamic performance and therapeutic efficacy of dry powder formulations. Furthermore, advances in top-down and bottom-up techniques in particle preparation, highlighting their roles in tailoring particle properties and optimizing therapeutic outcomes, are also presented. Practices adopted for particle engineering during the past 100 years indicate a significant transition in research and commercial interest in the strategies used, with several innovative concepts coming into play in the past decade. Accordingly, this article highlights futuristic particle engineering approaches such as electrospraying, inkjet printing, thin film freeze drying, and supercritical processes, including their prospects and associated challenges. With such technologies, it is possible to reshape inhaled therapeutic ingredient delivery, optimizing therapeutic benefits and improving the quality of life for patients with respiratory diseases and beyond.

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A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration

Abstract: Graphical AbstractAerogel powders are advantageous porous particles in dry powder inhalers for the pulmonary drug delivery in local and systemic treatments.

Cited by 27 publications

References 88 publications

Novel poly(ester amide) derived from tyrosine amino acid for targeted pulmonary drug delivery of fluticasone propionate

Novel poly(ester amide) derived from tyrosine amino acid for targeted pulmonary drug delivery of fluticasone propionate

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches

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