A patient with COVID-19 and anti-glomerular basement membrane disease

Koç, Neriman Sıla; Yıldırım, Tolga; Saglam, Arzu; Arıcı, Mustafa; Erdem, Yunus

doi:10.1016/j.nefro.2020.08.003

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Koc et al [ 5 ] reported the case of an 80-year-old lady with known anti-GBM disease who acquired COVID-19 infection during hospitalisation and succumbed to her illness after 14 days of hospital stay. The authors hypothesised that the poor outcome may have been due to the pre-existing lung pathology induced by anti-GBM disease.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Illness in a Patient With Anti-Glomerular Basement Membrane Disease: A Clinical Dilemma

Venkateswaran¹,

Chaturvedi²,

Soni³

et al. 2021

Cureus

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Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune disease affecting the kidneys and lungs. COVID-19 infection in a patient with pre-existing anti-GBM disease presents a unique set of clinical challenges. The formulation of a judicious treatment plan balancing both disease processes is tricky, especially with regard to anticoagulation. We present the case of a young patient with anti-GBM disease who acquired COVID-19 infection and eventually succumbed to his illness.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Illness in a Patient With Anti-Glomerular Basement Membrane Disease: A Clinical Dilemma

Venkateswaran¹,

Chaturvedi²,

Soni³

et al. 2021

Cureus

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“…In this setting, correctly identifying COVID-19-related morphologic features of kidney involvement will prove crucial for patient clinical management. Kidney biopsy performed during COVID-19 allows to identify a subset of morphological findings related to SARS-CoV-2 infection, such as collapsing glomerulopathy (CG) and other forms of focal segmental glomerulosclerosis, acute tubular necrosis (ATN), IgA nephropathy, thrombotic microangiopathy, crescentic glomerulonephritis, minimal change disease (MCD), membranous nephropathy, and anti-glomerular basement membrane disease ( Table 1 ) [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 ].…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Kidney Injury Following COVID-19 Disease: Renal Biopsy Findings in a Single Italian Pathology Service

et al. 2022

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The onset of coronavirus disease (COVID-19) as a pandemic infection, has led to increasing insights on its pathophysiology and clinical features being revealed, such as a noticeable kidney involvement. In this study, we describe the histopathological, immunofluorescence, and ultrastructural features of biopsy-proven kidney injury observed in a series of SARS-CoV-2 positive cases in our institution from April 2020 to November 2021. We retrieved and retrospectively reviewed nine cases (two pediatric and seven adults) that experienced nephrotic syndrome (six cases), acute kidney injury (two cases), and a clinically silent microhematuria and leukocyturia. Kidney biopsies were investigated by means of light microscopy, direct immunofluorescence, and electron microscopy. The primary diagnoses were minimal change disease (four cases), acute tubular necrosis (two cases), collapsing glomerulopathy (two cases), and C3 glomerulopathy (one case). None of the cases showed viral or viral-like particles on ultrastructural analysis. Novel and specific histologic features on kidney biopsy related to SARS-CoV-2 infection have been gradually disclosed and reported, harboring relevant clinical and therapeutic implications. Recognizing and properly diagnosing renal involvement in patients experiencing COVID-19 could be challenging (due to the lack of direct proof of viral infection, e.g., viral particles) and requires a proper integration of clinical and pathological data.

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