Spectrum of Kidney Injury Following COVID-19 Disease: Renal Biopsy Findings in a Single Italian Pathology Service

Gambella, Alessandro; Barreca, Antonella; Biancone, Luigi; Roccatello, Dario; Peruzzi, Licia; Besso, Luca; Licata, Carolina; Attanasio, A.; Papotti, Mauro; Cassoni, Paola

doi:10.3390/biom12020298

Cited by 18 publications

(16 citation statements)

References 137 publications

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“…The collected kidney biopsies were processed and set up for LM, IF, and EM assessments according to our laboratory clinical protocols for routine diagnostics, as previously reported [ 9 , 10 ].…”

Section: Methodsmentioning

confidence: 99%

DNAJB9 Is a Reliable Immunohistochemical Marker of Fibrillary Glomerulonephritis: Evaluation of Diagnostic Efficacy in a Large Series of Kidney Biopsies

et al. 2022

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Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by a challenging diagnostic workup requiring ultrastructural identification of 20 nm-thick randomly oriented fibrillar deposits. However, the recent introduction of DNAJB9 as a putative diagnostic marker of FGN could thoroughly improve this diagnostic scenario. This study aims to assess the DNAJB9 immunohistochemical expression in a large series of FGN cases and to eventually confirm its role as a diagnostic marker of FGN. We evaluated the immunohistochemical expression of DNAJB9 (Rabbit Polyclonal, ThermoFisher) in a series of 77 FGN and 128 non-FGN cases diagnosed between January 1992 and June 2022 at the Pathology Unit of the AOU Città della Salute e della Scienza Hospital. DNAJB9 was expressed in 73 of the 74 evaluable FGN cases, mostly showing a strong glomerular positivity (68 cases). Additionally, DNAJB9 resulted positive in all challenging scenarios [early-stage (6), congophilic (4), combined (4), and uncertain (4) cases of FGN)]. DNAJB9 was negative in all non-FGN cases, eventually resulting in a specificity of 100% and sensitivity of 99%. In conclusion, we confirmed the role of DNAJB9 as a diagnostic marker of FGN. Its adoption in the clinical routine will allow a faster, more feasible, and more accurate FGN diagnosis.

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Section: Methodsmentioning

confidence: 99%

DNAJB9 Is a Reliable Immunohistochemical Marker of Fibrillary Glomerulonephritis: Evaluation of Diagnostic Efficacy in a Large Series of Kidney Biopsies

et al. 2022

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“…It is now understood that the disease is more multifaceted, characterized by a wide range of symptom severity and affects people of all ages. Moreover, several organs are involved, but the kidneys are a particularly significant site of damage [12].…”

Section: Glomerulonephritis Associated With Anti-neutrophilmentioning

confidence: 99%

ANCA Glomerulonephritis after COVID-19 and post-COVID-19 vaccination – current state of knowledge

Tomasik,

Sajdak,

Ziajor

et al. 2024

J Pre Clin Clin Res.

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Introduction and Objective.In recent years, cases of secondary glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) have been reported following COVID-19 infection or vaccination against SARS-CoV-2. The aim of the study was to analyze publications related to this issue and to highlight both the benefits of vaccination and the potential for secondary immune responses to both infection and vaccination against COVID-19. Review Methods. A literature review was conducted on sources available up to December 2023, utilizing databases such as PubMed, Cochrane, and Google Scholar. The analysis included cases of ANCA-associated glomerulonephritis (ANCA-GN) following SARS-CoV-2 infection and after COVID-19 vaccination. Brief description of the state of knowledge. ANCA-associated vasculitis (AAV) is an inflammation of small and medium vessels affecting all systems, including the kidneys. Various causes contribute to the development of AAV, including pathogenic microorganisms and individual abnormal reactions to vaccinations, which can lead to autoimmunization. Since the Covid-19 pandemic, cases of ANCA-GN have been observed in patients without prior autoimmune diseases. The rapid progression of the COVID-19 pandemic led to a significant acceleration in the development of dedicated vaccines, thereby preventing a considerable number of deaths caused by the infection. Summary. ANCA-associated glomerulonephritis post COVID-19 can be linked to both infection and vaccination, which may act as triggers for autoimmune responses. These mechanisms require further investigation. Vaccine-induced ANCA-GN following COVID-19 vaccination is rare, and vaccinations represent an appropriate strategy to combat this disease.

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“…Of these 45 cases, only 21 cases have detailed clinical history available. 10 , 18 , 19 , 35 , 36 , 37 , 38…”

Section: Kidney Pathology Potentially Related To Covid-19mentioning

confidence: 99%

COVID-19 and Glomerular Diseases

Klomjit¹,

Zand²,

Cornell³

et al. 2023

Kidney International Reports

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Spectrum of Kidney Injury Following COVID-19 Disease: Renal Biopsy Findings in a Single Italian Pathology Service

Cited by 18 publications

References 137 publications

DNAJB9 Is a Reliable Immunohistochemical Marker of Fibrillary Glomerulonephritis: Evaluation of Diagnostic Efficacy in a Large Series of Kidney Biopsies

DNAJB9 Is a Reliable Immunohistochemical Marker of Fibrillary Glomerulonephritis: Evaluation of Diagnostic Efficacy in a Large Series of Kidney Biopsies

ANCA Glomerulonephritis after COVID-19 and post-COVID-19 vaccination – current state of knowledge

COVID-19 and Glomerular Diseases

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