A patient with Marchiafava–Bignami disease as a complication of diabetes mellitus treated effectively with cortico steroid

Suzuki, Yutaka; Oishi, Minoru; Ogawa, Kōichi; Kamei, Satoshi

doi:10.1016/j.jocn.2011.07.040

Cited by 26 publications

(21 citation statements)

References 13 publications

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“…In contrast to Suzuki's patient who had untreated and persistently elevated serum glucose and isolated lesion in the corpus callosum [6], our patient had a wide range of unstable and fluctuations of glycemic levels and abnormal neuroimaging findings showing altered signals involving the splenium of the corpus callosum and extracallosal white matter pathways (Figure 1). The pathophysiology of corpus callosum demyelination in MBD is not completely understood.…”

Section: Discussioncontrasting

confidence: 60%

“…Recently, Suzuki and colleagues reported the first nonalcoholic diabetic MBD case of a 37-year-old woman [6]. In contrast to Suzuki's patient who had untreated and persistently elevated serum glucose and isolated lesion in the corpus callosum [6], our patient had a wide range of unstable and fluctuations of glycemic levels and abnormal neuroimaging findings showing altered signals involving the splenium of the corpus callosum and extracallosal white matter pathways (Figure 1).…”

Section: Discussionmentioning

confidence: 70%

“…Treatment of MBD was usually empirically initiated with multivitamins [1, 6, 13], corticosteroids [6, 14, 15], stabilization of plasma glucose [6], and supportive care. Early correct diagnosis and prompt appropriate management may be critical in reversing the underlying pathophysiology in the early stage.…”

Section: Discussionmentioning

confidence: 99%

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Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient

Yadala

Luo

2013

Case Reports in Neurological Medicine

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Marchiafava-Bignami disease (MBD) is a rare neurological disorder mostly seen in alcoholic and malnourished patients with a pathognomonic hallmark of corpus callosum demyelination. MBD in nonalcoholics without malnutrition has rarely been reported. We report a case of MBD in a diabetic patient, without alcoholism or malnutrition, caused by a wide range of glycemic level fluctuations. A 38-year-old man presented with sudden onset of alteration in speech and multiple falls in three days. Neurologic examination showed dysarthria, dysmetria, and ataxia but, otherwise, normal cranial nerves, motor and sensory functions, and tendon reflexes. Brain MRI showed symmetric abnormalities in the splenium of the corpus callosum. In addition, demyelination was also observed in bilateral posterior limbs of the internal capsule and brachium ponti. His symptoms significantly improved after stabilization and normalization of his plasma glucose level and administration of multivitamins and corticosteroids. The underlying pathophysiology of the development of MBD in our case is likely to be osmotic stress from a wide range of glycemic fluctuations causing structural and functional disturbance of oligodendrocytes, which may be reversible in its early stage.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 70%

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Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient

Yadala

Luo

2013

Case Reports in Neurological Medicine

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“…1,5 However, until now, there have been no reports of a specific proven treatment for MBD. 1,3,5 In addition, it should be noted that nonalcoholic MBD may occur even in metabolic disorders with or without malnutrition, and advanced neuroimaging techniques such as MRI facilitate early diagnosis of MBD. 1 In conclusion, acute onset MBD is not always fatal, and complete recovery is possible after timely diagnosis and appropriate treatment.…”

Section: Discussionmentioning

confidence: 99%

Neurological and Psychiatric Findings of Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient With High Blood Glucose Levels

Kilinç

Ozbek²,

Özkan³

et al. 2015

JNP

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“…Type B shows a normal to slight impairment of consciousness, partial lesions, and a favorable outcome. A case of MBD with no history of alcoholism or malnutrition was reported in a patient with diabetes mellitus [5], although MBD has usually been reported in patients with alcoholism or malnutrition. We report a patient with MBD type A possibly superimposed on NPH in the absence of alcohol consumption or malnutrition and also in the setting of well controlled blood sugar level.…”

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confidence: 99%

Marchiafava Bignami Disease Potentially Complicating Normal Pressure Hydrocephalus

Lee

Yoo

Lee

et al. 2014

Dement Neurocognitive Disord

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Marchiafava-Bignami disease (MBD) is a rare disorder of demyelination or necrosis of the corpus callosum. Mainly, MBD is associated with alcohol and malnutrition. We report a 60-year-old woman with no history of alcohol consumption or malnutrition who had MBD as a possible complication of normal pressure hydrocephalus (NPH). The patient presented with a 2-month history of progressive gait unsteadiness, urinary incontinence, and forgetfulness, for which the patient underwent ventriculoperitoneal shunt surgery with remarkable improvement. Magnetic resonance imaging (MRI) demonstrated hyperintensity in the body and splenium of corpus callosum when she was brought to the hospital again with rapid deterioration of her mental ststus. It might be postulated that cerebrospinal fluid (CSF) tumor necrosis factoralpha (TNF-α) might have contributed to the development of MBD although not measured in this patient, given that TNF-α, as a proinflammatory cytokine mediating demyelinating process have been found in be increased in the CSF of NPH.

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A patient with Marchiafava–Bignami disease as a complication of diabetes mellitus treated effectively with cortico steroid

Cited by 26 publications

References 13 publications

Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient

Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient

Neurological and Psychiatric Findings of Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient With High Blood Glucose Levels

Marchiafava Bignami Disease Potentially Complicating Normal Pressure Hydrocephalus

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