A patient with SARS-CoV-2 infection during pregnancy in Qingdao, China

Wen, Rong; Sun, Yue; Xing, Quansheng

doi:10.1016/j.jmii.2020.03.004

Cited by 45 publications

(54 citation statements)

References 2 publications

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“…Most women showed mild or moderate symptoms, and three of them required intensive care. Preterm birth occurred in 8 out of 61 women who gave birth (Chen et al, 2020b;Chen et al, 2020c;Fan et al, 2020;Liu et al, 2020b;Liu et al, 2020c;Wang et al, 2020a;Wen et al, 2020;Zhu et al, 2020). A joint investigation carried out by the WHO and China evaluated 147 pregnant women in China (64 confirmed and 82 suspected COVID-19 cases and an asymptomatic patient), 8% showed severe symptoms, and 1% showed a critical course of disease.…”

Section: Covid-19 and Pregnancymentioning

confidence: 99%

A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments

Monteleone¹,

Nakano²,

Lazar³

et al. 2020

JBRA Assisted Reproduction

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The current outbreak of the novel 2019 coronavirus disease started in China in December 2019 and has since spread to several other countries. On March 25, 2020, a total of 375,498 cases had been confirmed globally with 2,201 cases in Brazil, showing the urgency of reacting to this international public health emergency. While in most cases, mild symptoms are observed, in some cases the infection leads to serious pulmonary disease. As a result, the possible consequences of the COVID-19 outbreak for pregnant women and its potential effects on the management of assisted reproductive treatments, demand attention. In this review, we summarize the latest research progress related to COVID-19 epidemiology and the reported data of pregnant women, and discuss the current evidence of COVID-19 infections during pregnancy and its potential consequences for assisted reproductive treatments. Reported data suggest that symptoms in pregnant women are similar to those in other people, and that there is no evidence for higher maternal or fetal risks. However, considering the initial data and lack of comprehensive knowledge on the pathogenesis of SARS-CoV-2 during pregnancy, human reproduction societies have recommended postponing the embryo transfers and do not initiate new treatment cycles. New evidence must be considered carefully in order to adjust these recommendations accordingly at any time and to guide assisted reproductive treatments.

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Section: Covid-19 and Pregnancymentioning

confidence: 99%

A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments

Monteleone¹,

Nakano²,

Lazar³

et al. 2020

JBRA Assisted Reproduction

View full text Add to dashboard Cite

show abstract

“…16 studies presented clinical findings of COVID-19 among pregnant women, which includes six original articles [12,13,[20][21][22]38], three case reports [15,32,33], two case-reviews [29,36], two research letters [18,37], and one correspondence [34], rapid review [24] and systematic review and meta-analysis [14] each. Out of these 16 studies, only 13 reported original data [12,13,15,18,[20][21][22]24,[32][33][34]37,38] and three study [14,29,31] reviewed data from existing studies ( Table 3). Cumulatively clinical features of 229 pregnant women were reported in this review -ranging from a single [18,[32][33][34]37] to 41 pregnant women [14,21].…”

Section: Resultsmentioning

confidence: 99%

“…Out of these 16 studies, only 13 reported original data [12,13,15,18,[20][21][22]24,[32][33][34]37,38] and three study [14,29,31] reviewed data from existing studies ( Table 3). Cumulatively clinical features of 229 pregnant women were reported in this review -ranging from a single [18,[32][33][34]37] to 41 pregnant women [14,21]. It is possible that duplication of clinical cases presents between studies -however -we have actively tried to remove duplicate findings from the result.…”

Section: Resultsmentioning

confidence: 99%

“…Real-time reverse transcription-polymerase chain reaction (RT-PCR) test was used for COVID-19 confirmation for all studies, except for Liu et al [21], where 25 participants (out of 41) were laboratory negative for SARS-CoV-2 but had clinical features of COVID-19. Seven studies reported both clinical findings and recommendations for the management of COVID-19 during pregnancy, which included four original articles [12,13,21,38], two casereports [15,33], and one correspondence [34]. Twelve studies exclusively discussed management recommendations.…”

Section: Resultsmentioning

confidence: 99%

“…Sore throat is the most common initial respiratory symptom; however, dyspnea and chest distress were also reported by pregnant women. Four studies reported gastrointestinal symptoms (diarrhea) [13,20,34,36]. Abdominal rash [15], and bilateral conjunctival hyperemia [37] were reported as atypical findings.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Pregnancy during the evolving pandemic Coronavirus Disease 2019 (COVID-19): A rapid scoping review of early evidence in the published literature

Hasan

Kibria

Alam

2020

Preprint

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BackgroundWithout any preventive or curative medication, the Coronavirus disease 2019 (COVID-19) poses a higher risk to pregnant women, due to their immunosuppression during pregnancy. This rapid scoping synthesized the earliest evidence from the published scientific literature on the clinical feature and management for pregnant women with COVID-19.MethodScientific literature (published in English between 1 January 2019 to 31 March 2020) were systematically extracted from PubMed, Embase, Scopus, Web of Science, and “Global research on coronavirus disease (COVID-19)”. Results from eligible studies were charted, synthesized, and presented in a narrative format. ResultOur study identified 52 unique articles, and among them, 29 were included in this review. Pregnant women with COVID-19 were mostly in their third trimester and presented with fever, dry cough, myalgia, and dyspnea. Ground-glass opacity was the cardinal feature of COVID-19 in the computerized tomography scan of the chest. Except for two participants, severe pneumonia did not occur among pregnant women. Higher episodes of preterm birth and cesarean delivery were observed; however, it cannot be explicitly attributed to COVID-19. There is no published evidence on the vertical transmission. A collaborative team of healthcare professionals must manage pregnancy with COVID-19. Contact tracing, investigation of travel history, radiological assessment, and laboratory tests with regular fetal health monitoring must be done. ConclusionEvidence of higher perinatal complications puts pregnant women in a further vulnerable condition. Cautiousness is imperative during the clinical management of pregnant women with COVID-19, as there is no approved treatment regime available at this moment.

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Delivery in pregnant women infected with SARS‐CoV‐2: A fast review

Parazzini

Bortolus

Mauri

et al. 2020

Intl J Gynecology & Obste

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Background: Few case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered. Objective:To review the available information on mode of delivery, vertical/peripartum transmission, and neonatal outcome in pregnant women infected with SARS-CoV-2.Search strategy: Combination of the following key words: COVID-19, SARS-CoV-2, and pregnancy in Embase and PubMed databases.Selection criteria: Papers reporting cases of women infected with SARS-CoV-2 who delivered. Data collection and analysis:The following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes. Main results:In the 13 studies included, vaginal delivery was reported in 6 cases (9.4%; 95% CI, 3.5-19.3). Indication for cesarean delivery was worsening of maternal conditions in 31 cases (48.4%; 95% CI, 35.8-61.3). Two newborns testing positive for SARS-CoV-2 by real-time RT-PCR assay were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated but the RT-PCR test was negative. Conclusions:The rate of vertical or peripartum transmission of SARS-CoV-2 is low, if any, for cesarean delivery; no data are available for vaginal delivery. Low frequency of spontaneous preterm birth and general favorable immediate neonatal outcome are reassuring. K E Y W O R D S

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A patient with SARS-CoV-2 infection during pregnancy in Qingdao, China

Cited by 45 publications

References 2 publications

A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments

A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments

Pregnancy during the evolving pandemic Coronavirus Disease 2019 (COVID-19): A rapid scoping review of early evidence in the published literature

Delivery in pregnant women infected with SARS‐CoV‐2: A fast review

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