A PDMS-Based Conical-Well Microelectrode Array for Surface Stimulation and Recording of Neural Tissues

Guo, Liang; Meacham, Kathleen; Hochman, Shawn; DeWeerth, Stephen P.

doi:10.1109/tbme.2010.2052617

Cited by 36 publications

(23 citation statements)

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“…Electrode material with a flexibility closer to that of brain tissues can reduce neural damage and inflammatory response. Many flexible polymers have been used to make neural electrode, including polyimide [ 182 , 183 ], parylene [ 184 ], PDMS [ 185 ] etc. Biocompatibility is always an important issue in electrode design because inflammatory response and encapsulation deteriorate signal quality over time and undermine the quality of chronic neural recordings.…”

Section: Main Textmentioning

confidence: 99%

Human motor decoding from neural signals: a review

Tam

Zhao

et al. 2019

BMC biomed eng

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Many people suffer from movement disability due to amputation or neurological diseases. Fortunately, with modern neurotechnology now it is possible to intercept motor control signals at various points along the neural transduction pathway and use that to drive external devices for communication or control. Here we will review the latest developments in human motor decoding. We reviewed the various strategies to decode motor intention from human and their respective advantages and challenges. Neural control signals can be intercepted at various points in the neural signal transduction pathway, including the brain (electroencephalography, electrocorticography, intracortical recordings), the nerves (peripheral nerve recordings) and the muscles (electromyography). We systematically discussed the sites of signal acquisition, available neural features, signal processing techniques and decoding algorithms in each of these potential interception points. Examples of applications and the current state-of-the-art performance were also reviewed. Although great strides have been made in human motor decoding, we are still far away from achieving naturalistic and dexterous control like our native limbs. Concerted efforts from material scientists, electrical engineers, and healthcare professionals are needed to further advance the field and make the technology widely available in clinical use.

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Section: Main Textmentioning

confidence: 99%

Human motor decoding from neural signals: a review

Tam

Zhao

et al. 2019

BMC biomed eng

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“…Additionally, molds for materials that are deposited by means of CVD are difficult to separate, and may require the use of adhesion-promoting or adhesion-demoting techniques to [ 67 ] help decouple the mold from the substrate. Molding is routinely used in the fabrication of non-penetrating arrays that lie on the surface of the target tissue, such as electrocorticography [ 69 ], spinal cord stimulation [ 70 ], and retinal prosthesis [ 71 ]. However, for neural probes, molding is most often relegated for coating devices with stiffeners or biologically-inspired chemicals, rather than for use in the fabrication of critical features.…”

Section: Probe Fabrication and Materials Selectionmentioning

confidence: 99%

Flexible, Penetrating Brain Probes Enabled by Advances in Polymer Microfabrication

2016

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The acquisition of high-fidelity, long-term neural recordings in vivo is critically important to advance neuroscience and brain–machine interfaces. For decades, rigid materials such as metal microwires and micromachined silicon shanks were used as invasive electrophysiological interfaces to neurons, providing either single or multiple electrode recording sites. Extensive research has revealed that such rigid interfaces suffer from gradual recording quality degradation, in part stemming from tissue damage and the ensuing immune response arising from mechanical mismatch between the probe and brain. The development of “soft” neural probes constructed from polymer shanks has been enabled by advancements in microfabrication; this alternative has the potential to mitigate mismatch-related side effects and thus improve the quality of recordings. This review examines soft neural probe materials and their associated microfabrication techniques, the resulting soft neural probes, and their implementation including custom implantation and electrical packaging strategies. The use of soft materials necessitates careful consideration of surgical placement, often requiring the use of additional surgical shuttles or biodegradable coatings that impart temporary stiffness. Investigation of surgical implantation mechanics and histological evidence to support the use of soft probes will be presented. The review concludes with a critical discussion of the remaining technical challenges and future outlook.

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“…PDMS is a Si based organic polymer widely used in micro fabrication and device encapsulation. Its bio-compatibility, high chemical inertness, as long as its mechanical property—flexible, but sturdy enough to tolerate bending across macroscopic scales, make it a very suitable and safe material [24] . Even for the transdermal drug delivery where the device is attached to the skin and there is less space restriction and less bio-safety consideration, the antenna-PDMS packaging assembly is still an advantageous solution.…”

Section: Low Cost Fabrication Of Antenna Sensorsmentioning

confidence: 99%

RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring

Huang

Zhao

Chen

et al. 2014

IEEE J. Transl. Eng. Health Med.

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Miniaturized helix antennas are integrated with drug reservoirs to function as RFID wireless tag sensors for real-time drug dosage monitoring. The general design procedure of this type of biomedical antenna sensors is proposed based on electromagnetic theory and finite element simulation. A cost effective fabrication process is utilized to encapsulate the antenna sensor within a biocompatible package layer using PDMS material, and at the same time form a drug storage or drug delivery unit inside the sensor. The in vitro experiment on two prototypes of antenna sensor-drug reservoir assembly have shown the ability to monitor the drug dosage by tracking antenna resonant frequency shift from 2.4–2.5-GHz ISM band with realized sensitivity of 1.27 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\mu~{\rm l}/{\rm MHz}$\end{document} for transdermal drug delivery monitoring and 2.76-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\mu~{\rm l}/{\rm MHz}$\end{document} sensitivity for implanted drug delivery monitoring.

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A PDMS-Based Conical-Well Microelectrode Array for Surface Stimulation and Recording of Neural Tissues

Cited by 36 publications

References 50 publications

Human motor decoding from neural signals: a review

Human motor decoding from neural signals: a review

Flexible, Penetrating Brain Probes Enabled by Advances in Polymer Microfabrication

RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring

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