A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films

Visser, Jan; Wibier, Lisa; Kiefer, Olga; Orlu, Mine; Breitkreutz, Jörg; Woerdenbag, Herman J.; Taxis, Katja

doi:10.3390/pharmaceutics12020164

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…This indicates that the ratio of cannabinoids was not affected by the process of inkjet printing. The outcomes of the drug content analysis suggest that inkjet printing of DEEP using desktop printers can be used to prepare flexible doses of APIs by simple manipulation of the digital design of the pattern to be printed, though it is more suitable for low dose APIs, as also pointed out by other studies [22,35].…”

Section: Drug Contentmentioning

confidence: 76%

Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release

et al. 2021

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Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit level. The aim of this study was to fabricate DEEP with a patient-tailored dose, modify drug release and design to meet patients’ preferences. It also aimed to investigate physical stability in terms of the readability of QR code patterns of DEEP during storage. Cannabinoids, namely, cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), were used as the model active pharmaceutical ingredients (APIs). Three different substrates and two colorants for the ink were tested for their suitability to fabricate DEEP by desktop inkjet printing. Flexible doses and customizable designs of DEEP were obtained by manipulating the digital design of the QR code, particularly, by exploring different pattern types, embedded images and the physical size of the QR code pattern. Modification of the release of both APIs from DEEP was achieved by applying a hydroxypropyl cellulose (HPC) polymer coating. The appearance and readability of uncoated and polymer-coated DEEP did not change on storage in cold and dry conditions; however, the HPC polymer layer was insufficient in preserving the readability of the QR code pattern in the extreme storage condition (40 °C and 75% relative humidity). To sum up, the DEEP concept provides opportunities for the personalization of medicines, considering also patients’ preferences.

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Section: Drug Contentmentioning

confidence: 76%

Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release

et al. 2021

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“…In the other study it was thought that the drug degraded during the production process [47]. Overall, the dosing precision was adequate, irrespective of the printing method used, though ink-based printing methods could be of specific interest for low-dose drugs [52,60].…”

Section: Pediatric-centered Formulation Designmentioning

confidence: 97%

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

et al. 2022

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3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population.

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“…The effective delivery of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics due to their poor solubility in water [1][2][3]. During the past several decades, a wide variety of efforts have been paid to potential solutions, including both from new pharmaceutical excipients [4][5][6] and new methods for converting them in suitable dosage forms [7][8][9]. In this nano era, nanotechnologies and their products are playing an increasingly important role in providing novel strategies for resolving this problem [10,11].…”

Section: Introductionmentioning

confidence: 99%

Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

Ning

Zhou

et al. 2021

Membranes

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The dissolution of poorly water-soluble drugs has been a longstanding and important issue in pharmaceutics during the past several decades. Nanotechnologies and their products have been broadly investigated for providing novel strategies for resolving this problem. In the present study, a new orodispersible membrane (OM) comprising electrospun nanofibers is developed for the fast dissolution of diclofenac sodium (DS). A modified coaxial electrospinning was implemented for the preparation of membranes, during which an unspinnable solution of sucralose was explored as the sheath working fluid for smoothing the working processes and also adjusting the taste of membranes. SEM and TEM images demonstrated that the OMs were composed of linear nanofibers with core-sheath inner structures. XRD and ATR-FTIR results suggested that DS presented in the OMs in an amorphous state due to the fine compatibility between DS and PVP. In vitro dissolution measurements and simulated artificial tongue experiments verified that the OMs were able to release the loaded DS in a pulsatile manner. The present protocols pave the way for the fast dissolution and fast action of a series of poorly water-soluble active ingredients that are suitable for oral administration.

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A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films

Cited by 14 publications

References 29 publications

Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release

Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

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