Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

Ning, Tingbao; Zhou, Yangjian; Xu, Haixia; Guo, Shiri; Wang, Ke; Yu, Deng‐Guang

doi:10.3390/membranes11110802

Cited by 55 publications

(40 citation statements)

References 79 publications

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“…The preparation of nanofibers by the “top-down” method is a simple, efficient, economical, and flexible method. As shown in Figure 2 , four key devices are needed to achieve this process: (1) a high-voltage generator; (2) an infusion pump, which can accurately control the speed of the distribution of the solution or melt; (3) a metal needle or spinneret; and (4) a collector [ 62 ]. After the resurgence of electrospinning in 1995, it was considered as a process of continuous splitting in the atomization region to produce nanofibers.…”

Section: Electrospinningmentioning

confidence: 99%

Electrospun Nanofiber Membranes for Air Filtration: A Review

et al. 2022

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Nanomaterials for air filtration have been studied by researchers for decades. Owing to the advantages of high porosity, small pore size, and good connectivity, nanofiber membranes prepared by electrospinning technology have been considered as an outstanding air-filter candidate. To satisfy the requirements of material functionalization, electrospinning can provide a simple and efficient one-step process to fabricate the complex structures of functional nanofibers such as core–sheath structures, Janus structures, and other multilayered structures. Additionally, as a nanoparticle carrier, electrospun nanofibers can easily achieve antibacterial properties, flame-retardant properties, and the adsorption properties of volatile gases, etc. These simple and effective approaches have benefited from the significate development of electrospun nanofibers for air-filtration applications. In this review, the research progress on electrospun nanofibers as air filters in recent years is summarized. The fabrication methods, filtration performances, advantages, and disadvantages of single-polymer nanofibers, multipolymer composite nanofibers, and nanoparticle-doped hybrid nanofibers are investigated. Finally, the basic principles of air filtration are concluded upon and prospects for the application of complex-structured nanofibers in the field of air filtration are proposed.

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Section: Electrospinningmentioning

confidence: 99%

Electrospun Nanofiber Membranes for Air Filtration: A Review

et al. 2022

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“…However, most of those nanofiber mats were prepared by a binding solution containing drugs and polymers. The electrospinning is developing along three directions; one is the large-scale production of new polymer nanofibers [ 23 ], the second is the multiple-fluid electrospinning for creating core shell [ 24 ], Janus [ 25 ], trilayer core shell [ 26 ], and other complicated nanostructures [ 27 ], and the third is the combination of electrospinning with other traditional techniques [ 28 ]. In this study, we combined liposomes prepared by ethanol infusion with electrospinning for the fabrication of novel wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Astragalus Polysaccharides/PVA Nanofiber Membranes Containing Astragaloside IV-Loaded Liposomes and Their Potential Use for Wound Healing

Yue

Liu

Pang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Delayed wound healing is a common and serious complication in diabetic patients, especially the slow healing of foot ulcers, which seriously affects the quality of life of patients and is also the most important risk factor for lower limb amputation. The multifunctional novel dressing prepared by loading the polymer nanofibers with anti-inflammatory and prohealing plant extracts can promote the wound repair of these ulcers by electrospinning technology. Liposomes are nanoparticles prepared from phospholipids and have been widely used as drug delivery systems. Liposomes can be combined with electrospun nanofibrous webs to facilitate local and sustained delivery of loaded bioactive substances. In this study, liposomes were prepared with astragaloside IV (AS) by employing a modified ethanol injection method and conducting the physical and chemical characterization (e.g., the particle size, polydispersity index, zeta potential, and entrapment efficiency). Astragalus polysaccharides were extracted from Astragalus membranaceus. Subsequently, we prepared the electrospun polyvinyl alcohol (PVA)/astragalus polysaccharide (APS)/astragaloside IV (AS) nanofibers. The morphology of the produced ASL/APS/PVA, APS/PVA, and PVA nanofibers were analyzed by scanning electron microscopy (SEM), and it turns out that the addition of astragalus extract made the fiber diameter smaller and the fibers arranged neatly with no dripping. An induced diabetic rat model was built, and a diabetic ulcer model was built by total cortical resection to assess the prorepair ability of the prepared nanofibers. According to in vivo animal experiments, the nanofibrous membrane loaded with APS and ASL was reported to inhibit the occurrence of wound inflammation, enhance the deposition of collagen fibers ( P < 0.05 ) and the repair of regenerated epithelium ( P < 0.05 ), and effectively strengthen the wound healing of diabetic rats ( P < 0.05 ). In brief, PVA-loaded APS/ASL nanofibrous membranes refer to a prominent wound healing dressing material, which can effectively facilitate the healing of diabetic wounds, and they are demonstrated to be highly promising for application in diabetic wound dressings and tissue engineering.

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“…During the past half a century, both pharmaceutical technologies and excipients broadly expanded to create novel functional materials for realizing a wide variety of modified release profiles of active ingredients, which show potential applications in drug delivery, food engineering, cosmetics, and so on [12][13][14][15][16][17][18][19]. These profiles typically include an immediate release (or pulsatile release or rapid/fast release) [20][21][22][23], sustained release [24][25][26][27][28][29], delayed release [30], biphasic release [31][32][33], and multiple-stage release in terms of the drug release rate.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

Guo

Zhang

et al. 2021

Polymers

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In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures.

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Orodispersible Membranes from a Modified Coaxial Electrospinning for Fast Dissolution of Diclofenac Sodium

Cited by 55 publications

References 79 publications

Electrospun Nanofiber Membranes for Air Filtration: A Review

Electrospun Nanofiber Membranes for Air Filtration: A Review

Astragalus Polysaccharides/PVA Nanofiber Membranes Containing Astragaloside IV-Loaded Liposomes and Their Potential Use for Wound Healing

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

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