A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy

Chang, Zhijian; Ye, Jia-Hai; Qi, Fen; Fang, Hongbao; Lin, Fei; Wang, Shuai; Mu, Cancan; Zhang, Wenchao; He, Weijiang

doi:10.1039/d0nj04461j

Cited by 13 publications

(11 citation statements)

References 51 publications

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“…Specifically, the acrylic polymer PBMA is well known for its biocompatibility, and it has been used to fabricate platforms for gene delivery [ 56 , 57 , 58 ]., Given its chemical properties and low toxicity, pDMAEMA has been largely utilized as non-viral gene delivery system [ 59 , 60 ]. Finally, PEG chains were introduced to make the surface of the NPs more hydrophilic and minimize the protein absorption, thus reducing the reticuloendothelial clearance [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Targeting Cancer Cells Overexpressing Folate Receptors with New Terpolymer-Based Nanocapsules: Toward a Novel Targeted DNA Delivery System for Cancer Therapy

et al. 2021

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Chemotherapeutics represent the standard treatment for a wide range of cancers. However, these agents also affect healthy cells, thus leading to severe off-target effects. Given the non-selectivity of the commonly used drugs, any increase in the selective tumor tissue uptake would represent a significant improvement in cancer therapy. Recently, the use of gene therapy to completely remove the lesion and avoid the toxicity of chemotherapeutics has become a tendency in oncotherapy. Ideally, the genetic material must be safely transferred from the site of administration to the target cells, without involving healthy tissues. This can be achieved by encapsulating genes into non-viral carriers and modifying their surface with ligands with high selectivity and affinity for a relevant receptor on the target cells. Hence, in this work we evaluate the use of terpolymer-based nanocapsules for the targeted delivery of DNA toward cancer cells. The surface of the nanocapsules is decorated with folic acid to actively target the folate receptors overexpressed on a variety of cancer cells. The nanocapsules demonstrate a good ability of encapsulating and releasing DNA. Moreover, the presence of the targeting moieties on the surface of the nanocapsules favors cell uptake, opening up the possibility of more effective therapies.

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Section: Discussionmentioning

confidence: 99%

Targeting Cancer Cells Overexpressing Folate Receptors with New Terpolymer-Based Nanocapsules: Toward a Novel Targeted DNA Delivery System for Cancer Therapy

et al. 2021

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“…Photosensitizer (Carrier) Drug [27] citric acid/CuS@Fe3O4 Doxorubicin [28] [(η6-p-cymene)Ru(2,3-bis(2-pyridyl)-benzoquinoxaline)(pyridine)] 2+ Ru (II) segments [29] Porphyrin Oxaliplatin-adamantane [30] Zinc phthalocyanine Coumarin [31] Cyclometallated Ir(III) complex Camptothecin [32] Cu2−xSe Doxorubicin [33] NaYF4:Yb/Tm-TiO2 Doxorubicin [34] Silver nanoparticles Doxorubicin [35] ZnO nanorods Daunorubicin [36] MnO2-Pt@Au25 Platinum (IV) prodrugs [37] Zinc phthalocyanine Ganetespib [38] Polyelectrolytes-NaYF4:Yb/Tm Doxorubicin [39] AgFeO2 Quercetin [40] MnFe2O4 Curcumin [40] Cr2Fe6O12 Curcumin [41] Ti3C2 MXene Doxorubicin [42] Ti3C2 MXene Metformin [43] MoS2 Doxorubicin [44] Boron-dipyrromethene Lenvatinib [45] porphyrin-containing Janus macromolecular brush Doxorubicin [46] mPEG-Hydrazone-Br2-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene Doxorubicin [47] Ir(III) Paclitaxel [48] Fe3O4@MnO2-Chlorin-e6 Traditional Chinese medicine For example, in 2019, Cui and co-workers [49] demonstrated a semiconducting polymer containing grafted polyethylene glycol. This polymer not only showed photodynamic activity, but it was also a suitable carrier to conjugate other chemotherapeutic drugs such as bromoisophosphoramide.…”

Section: Referencementioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

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“…2021 developed a self‐assembly polymeric platform for chemo‐ and photodynamic therapies and constructed a 2,6‐diBr‐Bodipy photosensitizer and MPEG as the hydrophilic side chain to encapsulate doxorubicin molecules that exhibit time‐ and dose‐dependent cytotoxicity. Furthermore, PS‐integrated MPEG‐Br 2 ‐Bodipy generated highly efficient singlet oxygen under light irradiation [21] . Particular representations have been reported from the literature above and emphasize that if BODIPY PS is integrated into a nanocarrier system, its cellular uptake and PDT effect are increased in aqueous solutions.…”

Section: Introductionmentioning

confidence: 98%

“…Furthermore, PS-integrated MPEG-Br 2 -Bodipy generated highly efficient singlet oxygen under light irradiation. [21] Particular representations have been reported from the literature above and emphasize that if BODIPY PS is integrated into a nanocarrier system, its cellular uptake and PDT effect are increased in aqueous solutions. By taking advantage of these systems, we developed a novel BODIPY-based photosensitizer that was encapsulated within a cellulose acetate (CA) polymeric capsule in the current study (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Diiodo‐BODIPY in Sodium Dodecyl Sulfate Stabilized Cellulose Acetate Capsules for Enhanced Singlet Oxygen Production in Aqueous Solution

Topel

2023

ChemistrySelect

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As drug delivery vehicles, polymeric capsules have become highly versatile structures to protect the active substrate from degradation, improve biocompatibility, and provide controlled release. In particular, encapsulation could become an efficient technique to implement these materials in physiological media if the active substrate is an insoluble compound in an aqueous solution. Herein, an iodinated BODIPY derivative as a photosensitizer (PS) was encapsulated in a cellulose acetate (CA) polymer via a precipitation method with 50.8-71.8 % of encapsulation efficiency to enable the singlet oxygen production ( 1 O 2 ) in aqueous media. The prepared PS/CA capsules were stable for 10 days in PBS buffer with PdI values between 0.264-0.698 and produced 1 O 2 under 532 nm LED light efficiently. This work discusses the size effects of PS-loaded CA capsules on stability in solution, photophysical property, encapsulation efficiency, thermal stability, leakage behavior, and PDT activity. Additionally, under different UV light doses, the 1 O 2 generation of the PS/CA capsules were studied systematically.

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A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy

Abstract: A novel chemo-photodynamic combined therapeutic self-assembly polymeric platform (MPEG-Hyd-Br2-BODIPY) was constructed based on 2,6-diBr-BODIPY as the photosensitizer core and MPEG as the hydrophilic side chain through hydrazone bond linkage and...

Cited by 13 publications

References 51 publications

Targeting Cancer Cells Overexpressing Folate Receptors with New Terpolymer-Based Nanocapsules: Toward a Novel Targeted DNA Delivery System for Cancer Therapy

Targeting Cancer Cells Overexpressing Folate Receptors with New Terpolymer-Based Nanocapsules: Toward a Novel Targeted DNA Delivery System for Cancer Therapy

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

Encapsulation of Diiodo‐BODIPY in Sodium Dodecyl Sulfate Stabilized Cellulose Acetate Capsules for Enhanced Singlet Oxygen Production in Aqueous Solution

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