A Personalized Multi-Component Lifestyle Intervention Program Leads to Improved Quality of Life in Persons with Chronic Kidney Disease

Abstract

Introduction: Lifestyle interventions have been shown to produce favorable changes in some health outcomes in patients with chronic kidney disease (CKD). However, few such studies, employing real world methods have been completed in patients with CKD. Objective: This study tested the effectiveness of a comprehensive, multicomponent, lifestyle intervention, delivered through individualized counseling on a variety of health outcomes in pre-dialysis CKD patients. Methods: Eligible patients were assigned randomly to the intervention (TR) or usual care group (UC). A six-month home-based program involving personalized counseling to increase physical activity to recommended levels among stage G3a to G4 CKD patients while exchanging plant proteins for animal proteins was implemented. Physical function, cardiovascular function, dietary intake, medication use, and health-related quality of life (HRQOL) were assessed at baseline and after 1-month, 3-months (M3) and 6-months (M6). Results: Forty-two, patients (age 60.2 ± 9.2, BMI 34.5 ± 7.8) participated in this study (TR=27 UC=15). The intervention reduced (p<0.05) brachial (bSBP) and central systolic blood pressures (cSBP) at month 3 (M3) but both were attenuated at month 6 (M6). Scores on the effect of kidney disease subscale of the HRQOL measure improved in the intervention group at M3 and M6. There was no change in the other measures of HRQOL or in any physical function scores. Conclusions: This personalized multi-component lifestyle intervention enabled CKD patients to self-report fewer concerns with how CKD affected their daily lives independent of changes in physical function. Key words: Home-based exercise programs, plant-based nutrition

Physical Activity and Quality of Life in Hemodialysis Patients and Healthy Controls: A Cross-Sectional Study

“…Our results, along with other studies that showed the importance of physical activity for quality of life in HD patients, have significant value in designing the multicomponent lifestyle interventions involving physical exercise. This was confirmed by a novel study that showed that multi-component lifestyle intervention improved a variety of health outcomes in CKD patients [ 37 ]. Moreover, Mustata et al [ 38 ] showed that long-term exercise training improved HRQOL in patients on predialysis, while Ota et al [ 39 ] reported that a program including stretching and isotonic muscle conditioning improved components of daily living in elderly hemodialysis patients.…”

Functional Status and Engagement in Physical Activity Among Maintenance Dialysis Patients: A Mixed Methods Study

“…Structured exercise or physical activity interventions in this population 3 , 4 , 5 have improved functional abilities, reversed sarcopenia, and enhanced health-related quality of life. 5 , 6 , 7 Despite significant resources devoted to increasing the rehabilitative outcomes of this vulnerable population, 8 considerable work remains to develop effective, sustainable, patient-centered strategies geared toward the preservation of functional status.…”