A perspective on the developmental toxicity of inhaled nanoparticles

Hougaard, Karin Sørig; Campagnolo, Luisa; Chavatte‐Palmer, Pascale; Tarrade, Anne; Rousseau-Ralliard, Delphine; Valentino, Sarah; Park, Margriet V. D. Z.; Jong, Wim H. de; Wolterink, Gerrit; Piersma, Aldert H.; Ross, Bryony L.; Hutchison, Gary R; Hansen, Jitka Stilund; Vogel, Ulla; Jackson, Petra; Slama, Rémy; Pietroiusti, Antonio; Cassee, Flemming R.

doi:10.1016/j.reprotox.2015.05.015

Cited by 158 publications

(135 citation statements)

References 171 publications

(277 reference statements)

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…Bronchial epithelial cells exposed to PM10 led to the activation of cholesterol and lipid synthesis [23]. PM are also reported to cross the fetomaternal interface leading to developmental delay and/or malformations [2,24]. Stem cells play an active role not only during the embryonic development but also in later life where they are associated with continuous turnover of cells of the skin, haematopoietic and the intestinal system [25].…”

Section: Of 12mentioning

confidence: 99%

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

Abu‐Elmagd

Alghamdi

Shamy

et al. 2017

Preprint

View full text Add to dashboard Cite

Particulate matter (PM) contains heavy metals that affect various cellular functions and gene expression associated with an array of acute and chronic diseases, in humans. However, their specific effects on the stem cells remain unclear. Here, we report the effects of PM collected from Jeddah city on bone marrow mesenchymal stem cells (BM-MSCs) on proliferation, cell death, related gene expression and systems biological analysis aiming to understand the underlying mechanisms. Two different sizes (PM2.5-10) were tested in vitro at various concentrations (15 to 300 µg/ml) and durations (24 to 72 h). PMs induced cellular stress including membrane damage, shrinkage and death. Lower concentrations of PM2.5 increased BM-MSCs proliferation, while higher concentrations decreased it. PM10 decreased BM-MSCs proliferation in a concentration-dependant manner. The XRay Fluorescence spectrometric analysis showed that PM contains high levels of heavy metals. Ingenuity Pathway Analysis (IPA) and hierarchical clustering analyses showed that heavy metals were associated with signalling pathways involving cell stress/death, cancer and chronic diseases. qRT-PCR results showed differential regulation of the apoptosis genes (BCL2, BAX); upregulation of inflammation associated genes (TNF-α and IL-6) and downregulation of cell cycle regulation gene (P53). We conclude that PM could affect different cellular functions and predispose to debilitating diseases.

show abstract

Section: Of 12mentioning

confidence: 99%

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

Abu‐Elmagd

Alghamdi

Shamy

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…Les effets de l'inhalation sont importants et semblent parfois plus marqués que pour les autres voies. Une partie des résultats présentés ici a fait l'objet de revues récentes (Ema et al 2013 ;Hougaard et al 2015).…”

Section: Administration N'utilisant Pas La Voie Pulmonaire : Gavage Ounclassified

Exposition aux gaz d’échappement diesel durant la gestation : quelles conséquences sur le développement foeto-placentaire ? Apport des modèles animaux

Valentino¹,

Tarrade²,

Chavatte‐Palmer³

2016

bavf

Self Cite

View full text Add to dashboard Cite

La pollution atmosphérique est un problème majeur pour la santé humaine, causant 3,7 millions de décès prématurés en 2012 dans le monde. Les personnes âgées, les enfants ou les asthmatiques sont les cibles des messages de prévention lors de pics de pollution alors que les femmes enceintes sont le plus souvent négligées. Pourtant, les études épidémiologiques et les travaux sur les modèles animaux indiquent que la pollution atmosphérique et ses composants peuvent perturber la fonction placentaire, réduire la croissance foetale et induire un stress oxydant et une inflammation. A long terme, ces effets peuvent participer à l'augmentation des risques de maladies métaboliques chez l'adulte. Il est donc important d'inclure les femmes enceintes dans les messages de prévention lors de pics de pollution atmosphérique et de continuer la recherche sur les effets à long terme grâce au recours aux modèles animaux.

show abstract

“…Considering the complicated and sensitive nature of pregnancy, exposure during this time should also be considered. Few have demonstrated a link between xenobiotic exposure and untoward maternal and fetal health (7,23,115); within these, studies focusing on the vascular and/or neurological effects are severely lacking (56). The neurological outcomes associated with gestational exposures are especially interesting, given that the BBB is being developed during fetal maturation.…”

Section: Future Directions/studiesmentioning

confidence: 99%

Xenobiotic pulmonary exposure and systemic cardiovascular response via neurological links

Stapleton

Abukabda

Hardy

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

The cardiovascular response to xenobiotic particle exposure has been increasingly studied over the last two decades, producing an extraordinary scope and depth of research findings. With the flourishing of nanotechnology, the term "xenobiotic particles" has expanded to encompass not only air pollution particulate matter (PM) but also anthropogenic particles, such as engineered nanomaterials (ENMs). Historically, the majority of research in these fields has focused on pulmonary exposure and the adverse physiological effects associated with a host inflammatory response or direct particle-tissue interactions. Because these hypotheses can neither account entirely for the deleterious cardiovascular effects of xenobiotic particle exposure nor their time course, the case for substantial neurological involvement is apparent. Indeed, considerable evidence suggests that not only is neural involvement a significant contributor but also a reality that needs to be investigated more thoroughly when assessing xenobiotic particle toxicities. Therefore, the scope of this review is several-fold. First, we provide a brief overview of the major anatomical components of the central and peripheral nervous systems, giving consideration to the potential biologic targets affected by inhaled particles. Second, the autonomic arcs and mechanisms that may be involved are reviewed. Third, the cardiovascular outcomes following neurological responses are discussed. Lastly, unique problems, future risks, and hurdles associated with xenobiotic particle exposure are discussed. A better understanding of these neural issues may facilitate research that in conjunction with existing research, will ultimately prevent the untoward cardiovascular outcomes associated with PM exposures and/or identify safe ENMs for the advancement of human health.

show abstract

A perspective on the developmental toxicity of inhaled nanoparticles

Cited by 158 publications

References 171 publications

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches

Exposition aux gaz d’échappement diesel durant la gestation : quelles conséquences sur le développement foeto-placentaire ? Apport des modèles animaux

Xenobiotic pulmonary exposure and systemic cardiovascular response via neurological links

Contact Info

Product

Resources

About