2023
DOI: 10.1002/chem.202203865
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A pH‐Activatable Prodrug and Metal Prodrug Conjugate of Gossypol: Synthesis, Emergent Photophysical, Nanoscopic, Computational, and in‐Vitro Cellular Studies

Abstract: The major hurdle to the success of many potent chemotherapeutic drugs is the lack of stability of their active form suited for a particular mode of action. Efforts are needed to stabilize such functionalities by employing new and novel strategies to overcome challenges. In this study, tumorenvironment-specific, pH-activatable prodrug and metal-prodrug conjugate has been developed to ameliorate the side effects of chemotherapeutic drugs bearing reactive functionalities. As a proof of concept, a pre-clinically t… Show more

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Cited by 3 publications
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