A pH and hyaluronidase dual-responsive multilayer-based drug delivery system for resisting bacterial infection

Ayaz, Pirah; Xu, Bingjie; Zhang, Xiansheng; Wang, Jiping; Yu, Dan; Wu, Jindan

doi:10.1016/j.apsusc.2020.146806

Cited by 33 publications

(22 citation statements)

References 46 publications

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“…Smart nanocarriers can be engineered to release their payload in response to an internal stimulus that is specific to cancer microenvironments such as pH, ions, hypoxia, enzymes or proteins. Additionally, an external stimulus such as light, heat, magnetic field, and ultrasound can be used to control the payload release (Figure 1) [19][20][21][22]. Furthermore, dual or multi-responsive smart nanocarriers have been developed to further ascertain the targeted release.…”

Section: Smart Nanoplatformsmentioning

confidence: 99%

“…Oxidoreductases [41], proteases [42], phosphatases, kinases, transferases [43], and hydrolases, are typical enzyme groups relevant to the tumor microenvironment [44]. Among them, matrix metalloproteinases (MMPs), cathepsin B [45], and hyaluronidase (HAase) [21,46,47] are commonly employed in nanomedicine which incorporate the substrate of enzymes or moieties that can be recognized and degraded by these enzymes. Their catalytic mechanisms include the reduction/oxidation of substrates and the formation/cleavage of chemical bonds.…”

Section: Enzymesmentioning

confidence: 99%

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Smart Nanoparticles for Chemo-Based Combinational Therapy

et al. 2021

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Cancer is a heterogeneous and complex disease. Traditional cancer therapy is associated with low therapeutic index, acquired resistance, and various adverse effects. With the increasing understanding of cancer biology and technology advancements, more strategies have been exploited to optimize the therapeutic outcomes. The rapid development and application of nanomedicine have motivated this progress. Combinational regimen, for instance, has become an indispensable approach for effective cancer treatment, including the combination of chemotherapeutic agents, chemo-energy, chemo-gene, chemo-small molecules, and chemo-immunology. Additionally, smart nanoplatforms that respond to external stimuli (such as light, temperature, ultrasound, and magnetic field), and/or to internal stimuli (such as changes in pH, enzymes, hypoxia, and redox) have been extensively investigated to improve precision therapy. Smart nanoplatforms for combinational therapy have demonstrated the potential to be the next generation cancer treatment regimen. This review aims to highlight the recent advances in smart combinational therapy.

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Section: Smart Nanoplatformsmentioning

confidence: 99%

Section: Enzymesmentioning

confidence: 99%

Smart Nanoparticles for Chemo-Based Combinational Therapy

et al. 2021

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“…Bacterial infection might also appear with medical implants, as bacteria can colonize and thrive on top of the implant surface, and even generating a biofilm. [79,80] Many attempts were made to create an LBL coating for medical devices, to provide an antimicrobial treatment for the implantation site. Yet, all of them posed a repeating problem, which is provoking bacterial resistance.…”

Section: Multilayer Ddsmentioning

confidence: 99%

Recent Advances for Improving Functionality, Biocompatibility, and Longevity of Implantable Medical Devices and Deliverable Drug Delivery Systems

Kutner

Kunduru

Rizik

et al. 2021

Adv Funct Materials

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The great majority of medical devices elicit foreign body response (FBR) postimplantation. FBR is a major hurdle to develop a successful device for impaired organs, leading to failure of devices/treatments. In recent times, several advantageous technologies have been developed based on either surface modifications or localized drug delivery systems (DDSs) in order to overcome the FBR limitation, which enhanced the success of implantable medical devices. The recent advances for improving the functionality, biocompatibility, and longevity of implantable medical devices and deliverable DDSs are discussed here. It is believed that these advances will further guarantee the improvement of existing implants and deliverable entities while enabling the development of new therapy technologies. Such technologies are anticipated to be long-term patient-friendly and thus lead to a higher quality of life.

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“…HA is also a polyanion glycosaminoglycan that can repel most negatively-charged proteins and bacteria with negatively-charged cell membranes by electrostatic repulsive force. Conversely, it would be able to electrostatically attract cationic antimicrobial such as chitosan [ 17 , 18 ], quaternary ammonium salts [ 19 , 20 ], and cationic antimicrobial peptides [ 21 ] to integrate antibacterial function. Hence, HA is suitable for the surface modification of materials to reach the ultimate purpose of reducing bacterial adhesion [ 11 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Antifouling Property of Polyurethane Film Modified by PHMG and HA Using Layer-by-Layer Assembly

et al. 2021

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To reduce the possibility of bacterial infection and implant-related complications, surface modification on polyurethane (PU) film is an ideal solution to endow hydrophobic PU with antibacterial and antifouling properties. In this work, a variety of polyhexamethylene guanidine/ hyaluronic acid (PHMG/HA) multilayer films were self-assembled layer-by-layer on PU films using polyanions, carboxyl-activated HA, and polycations PHMG by controlling the concentration of these polyelectrolytes as well as the number of layers self-assembled. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) spectra, water contact angle (WCA), and A Atomic force microscope (AFM) of PU and modified PU films were studied. Protein adsorption and bacterial adhesion as well as the cytotoxicity against L929 of the film on selected PU-(PHMG/HA)5/5-5 were estimated. The results showed that PU-(PHMG/HA)5/5-5 had the best hydrophilicity among all the prepared films, possessing the lowest level of protein adsorption. Meanwhile, this film showed efficient broad-spectrum antibacterial performance as well as significant resistance of bacterial adhesion of more than a 99.9% drop for the selected bacteria. Moreover, almost no influence on cell viability of L929 enhanced the biocompatibility of film. Therefore, the modified PU films with admirable protein absorption resistance, antimicrobial performance, and biocompatibility would have promising applications in biomedical aspect.

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A pH and hyaluronidase dual-responsive multilayer-based drug delivery system for resisting bacterial infection

Cited by 33 publications

References 46 publications

Smart Nanoparticles for Chemo-Based Combinational Therapy

Smart Nanoparticles for Chemo-Based Combinational Therapy

Recent Advances for Improving Functionality, Biocompatibility, and Longevity of Implantable Medical Devices and Deliverable Drug Delivery Systems

Preparation and Antifouling Property of Polyurethane Film Modified by PHMG and HA Using Layer-by-Layer Assembly

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