A pH/GSH dual responsive nanoparticle with relaxivity amplification for magnetic resonance imaging and suppression of tumors and metastases

Zhu, Xianglong; Xiong, Hehe; Yang, Pei; Wang, Songwei; Zhou, Qiuju; Zhao, Zhenghuan; Shi, Saige

doi:10.1039/d2nr05449c

Cited by 5 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Mn ions have been discovered to amplify their T 1 relaxation by prolonging the correlation time (τ R ) through binding on protein. , Based on this finding, we investigated the T 1 relaxation amplification effect caused by protein correlated with the GSH-abundant environment-responding Worm-like. Worm-like shows T 1 relaxation amplification by bovine albumin (BSA) under both mild acidic and neutral environments in the presence of GSH (Figure H and Figure S23).…”

Section: Resultsmentioning

confidence: 99%

Magnetic Field-Optimized Paramagnetic Nanoprobe for T₂/T₁ Switchable Histopathological-Level MRI

Huo,

Zeng,

Wang

et al. 2024

ACS Nano

Self Cite

View full text Add to dashboard Cite

Traditional magnetic resonance imaging (MRI) contrast agents (CAs) are a type of "always on" system that accelerates proton relaxation regardless of their enrichment region. This "always on" feature leads to a decrease in signal differences between lesions and normal tissues, hampering their applications in accurate and early diagnosis. Herein, we report a strategy to fabricate glutathione (GSH)-responsive one-dimensional (1-D) manganese oxide nanoparticles (MONPs) with improved T 2 relaxivities and achieve effective T 2 /T 1 switchable MRI imaging of tumors. Compared to traditional contrast agents with high saturation magnetization to enhance T 2 relaxivities, 1-D MONPs with weak M s effectively increase the inhomogeneity of the local magnetic field and exhibit obvious T 2 contrast. The inhomogeneity of the local magnetic field of 1-D MONPs is highly dependent on their number of primary particles and surface roughness according to Landau−Lifshitz−Gilbert simulations and thus eventually determines their T 2 relaxivities. Furthermore, the GSH responsiveness ensures 1-D MONPs with sensitive switching from the T 2 to T 1 mode in vitro and subcutaneous tumors to clearly delineate the boundary of glioma and metastasis margins, achieving precise histopathological-level MRI. This study provides a strategy to improve T 2 relaxivity of magnetic nanoparticles and construct switchable MRI CAs, offering high tumor-to-normal tissue contrast signal for early and accurate diagnosis.

show abstract

Section: Resultsmentioning

confidence: 99%

Magnetic Field-Optimized Paramagnetic Nanoprobe for T₂/T₁ Switchable Histopathological-Level MRI

Huo,

Zeng,

Wang

et al. 2024

ACS Nano

Self Cite

View full text Add to dashboard Cite

show abstract

Multi‐Metallic Nanosheets Reshaping Immunosuppressive Tumor Microenvironment through Augmenting cGAS‐STING Innate Activation and Adaptive Immune Responses for Cancer Immunotherapy

Peng,

Liang,

Liu

et al. 2024

Advanced Science

View full text Add to dashboard Cite

The highly immunosuppressive tumor microenvironment (TME) restricts the efficient activation of immune responses. To restore the surveillance of the immune system for robust activation, vast efforts are devoted to normalizing the TME. Here, a manganese‐doped layered double hydroxide (Mn‐LDH) is developed for potent anti‐tumor immunity by reversing TME. Mn‐LDH is synthesized via a one‐step hydrothermal method. In addition to the inherent proton neutralization capacity of LDH, the introduction of manganese oxide endows LDH with an additional ability to produce oxygen. Mn‐LDH effectively releases Mn2+ and Mg2+ upon exposure to TME with high levels of H+ and H2O2, which activates synthase‐stimulator of interferon genes pathway and maintains the cytotoxicity of CD8+ T cells respectively, achieving a cascade‐like role in innate and adaptive immunity. The locally administered Mn‐LDH facilitated a “hot” network consisting of mature dendritic cells, M1‐phenotype macrophages, as well as cytotoxic and helper T cells, significantly inhibiting the growth of primary and distal tumors. Moreover, the photothermal conversion capacity of Mn‐LDH sparks more robust therapeutic effects in large established tumor models with a single administration and irradiation. Overall, this study guides the rational design of TME‐modulating immunotherapeutics for robust immune activation, providing a clinical candidate for next‐generation cancer immunotherapy.

show abstract

Glutathione-Responsive T1 Contrast Agent for Tumor Imaging

Wang,

Ye,

Qin

et al. 2023

Appl Magn Reson

View full text Add to dashboard Cite

A pH/GSH dual responsive nanoparticle with relaxivity amplification for magnetic resonance imaging and suppression of tumors and metastases

Abstract: Engineered magnetic nanoparticles combining diagnosis and therapy functions into one entity hold great potential to rejuvenate cancer treatment, however, they are still constrained by the “always on” signals and unsatisfactory...

Cited by 5 publications

References 60 publications

Magnetic Field-Optimized Paramagnetic Nanoprobe for T₂/T₁ Switchable Histopathological-Level MRI

Magnetic Field-Optimized Paramagnetic Nanoprobe for T₂/T₁ Switchable Histopathological-Level MRI

Multi‐Metallic Nanosheets Reshaping Immunosuppressive Tumor Microenvironment through Augmenting cGAS‐STING Innate Activation and Adaptive Immune Responses for Cancer Immunotherapy

Glutathione-Responsive T1 Contrast Agent for Tumor Imaging

Contact Info

Product

Resources

About

A pH/GSH dual responsive nanoparticle with relaxivity amplification for magnetic resonance imaging and suppression of tumors and metastases

Abstract: Engineered magnetic nanoparticles combining diagnosis and therapy functions into one entity hold great potential to rejuvenate cancer treatment, however, they are still constrained by the “always on” signals and unsatisfactory...

Cited by 5 publications

References 60 publications

Magnetic Field-Optimized Paramagnetic Nanoprobe for T2/T1 Switchable Histopathological-Level MRI

Magnetic Field-Optimized Paramagnetic Nanoprobe for T2/T1 Switchable Histopathological-Level MRI

Multi‐Metallic Nanosheets Reshaping Immunosuppressive Tumor Microenvironment through Augmenting cGAS‐STING Innate Activation and Adaptive Immune Responses for Cancer Immunotherapy

Glutathione-Responsive T1 Contrast Agent for Tumor Imaging

Contact Info

Product

Resources

About

Magnetic Field-Optimized Paramagnetic Nanoprobe for T₂/T₁ Switchable Histopathological-Level MRI

Magnetic Field-Optimized Paramagnetic Nanoprobe for T₂/T₁ Switchable Histopathological-Level MRI