A pharmacological profile of propoxazepam — a new antiepileptic substance

Abstract

Epilepsy refers to chronic polyethyologic diseases of the brain characterized by recurrent seizures that occur as a result of excessive neuronal discharges and are accompanied by various clinical and paraclinical symptoms. Anticonvulsant therapy remains the basis for treating patients with epilepsy, which involves the inhibition or a significant reduction in the number of attacks. Currently, the term "antiepileptic" is synonymous with anticonvulsant agents, as they all selectively suppress seizure, and their use is determined predominantly by the nature of paroxysmal manifestations or their equivalents. Depending on the clinical manifestations of epilepsy, different anticonvulsants can be prescribed. Often, for the treatment of epilepsy, the combined use of several medicines is rational (simultaneously or sequentially). Therefore, the success of a treatment of epilepsy is on the way to finding new anticonvulsants, which would have had an effect on different pathogenetic links in the formation of all variabilities of seizure states [1]. Antiepileptic drugs act on different molecular targets, selectively changing the excitability of neurons in such a way that the neuronal activity, associated with attacks, is blocked without disturbing the normal activity required to transmit signals between neurons. Various mecha

Пропоксазепам — Новаторський Анальгетичний Засіб, Що Гальмує Гострий Та Хронічний Біль І Має Полімодальний Механізм Дії

“…Зміна часу настання судом та їх перерозподіл у перебігу епілептичного синдрому свідчать про перспективність пропоксазепаму і в лікуванні деяких форм епілепсії. На підставі отриманих результатів розраховано основні показники (терапевтичний індекс, терапевтична широта, терапевтичний інтервал та фактор надійної безпеки), що характеризують безпечність застосування пропоксазепаму [42,43].…”