A phase I dose-escalation trial of intraperitoneal oxaliplatin with systemic capecitabine and bevacizumab following cytoreduction in patients with peritoneal carcinomatosis from appendiceal or colorectal cancer.
Abstract:746 Background: Peritoneal carcinomatosis (PC) is the intraperitoneal spread of cancer. Optimal treatment for PC is controversial. Systemic chemotherapy offers limited benefit (Franko, 2011). Intraperitoneal (IP) chemotherapy following cytoreductive surgery (CRS) improves outcomes (Verwaal, 2008). Oxaliplatin (Ox), capecitabine, and bevacizumab are standard agents for the treatment of metastatic colorectal cancer (CRC). Evidence suggests benefit of IP Ox at high doses. However, the optimal dose of IP Ox combi… Show more
Cancers of gastrointestinal tract constitute one of the most common cancer types worldwide and a ~58% increase in the global number of cases has been estimated by IARC for the...
Cancers of gastrointestinal tract constitute one of the most common cancer types worldwide and a ~58% increase in the global number of cases has been estimated by IARC for the...
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