A Phase III, Randomized, Double-Blind, Matched-Pairs, Active-Controlled Clinical Trial and Preclinical Animal Study to Compare the Durability, Efficacy and Safety between Polynucleotide Filler and Hyaluronic Acid Filler in the Correction of Crow's Feet: A New Concept of Regenerative Filler

Abstract

The Rejuran® is a new filler product made from purified polynucleotides. Here we present data from an animal study and a clinical trial to examine the durability, efficacy and safety of the Rejuran® on crow's feet. For the animal study, 25 mice were divided into three groups: Group 1 received phosphate buffered saline (PBS); Group 2 were treated with Yvoire®; and Group 3 were treated with Rejuran®. The durability and efficacy of each treatment were assessed by microscopy and staining. In the clinical trial, 72 patients were randomized to receive Rejuran® treatment for crow's feet on one side and Yvoire-Hydro® on the contralateral side, at a ratio of 1:1. Repeated treatments were performed every two weeks for a total of three times, over a total of 12 weeks' observation. All injections and observations of efficacy and safety were performed by the same two investigators. In the animal study, the Rejuran® group showed similar durability and inflammatory response to the Yvoire® group. Upon efficacy assessment, the Rejuran® group showed the greatest elasticity and collagen composition, and a significant difference in skin surface roughness and wrinkle depth. In the clinical trial, the primary and secondary objective efficacy outcome measure showed no statistical significance between the two groups, and in safety outcomes there were no unexpected adverse effects. Our data suggest that the Rejuran®, as a new regenerative filler, can be useful to reduce wrinkles, by showing evidence for its efficacy and safety.Graphical Abstract

Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients

“…The clinical comparing trial demonstrated the durability, efficacy, and safety of Rejuran ® . It showed similar durability to hyaluronic acid filler and also showed a similar safety .…”

Treatments of Infra-Orbital Dark Circles by Various Etiologies

“…In a comparison study with HA fillers, PN fillers showed greater increases in skin elasticity and collagen synthesis followed by fibroblast stimulation compared to HA filler groups with similar durability. PN fillers showed similarly good efficacy and safety in the correction of crow's feet in a clinical study 27 . In treating our patients, injection of a PN filler (Rejuran Ⓡ ; Pharmareasearch Products, Inc., Seongnam, Korea) is performed intradermally with a 33-gauge nanoneedle using a serial puncture technique, with injections placed approximately 1 cm apart over both infraorbital areas.…”

An update review on recent skin fillers

“…There are now over 35 major filler product companies worldwide. [1] In 2014, there were 2.3 million soft-tissue filler procedures in the United States, an increase of 3% from 2013. [2] The days of treating a nasolabial fold with single skin filler injection is gone, and a new era of more sophisticated approach of thoughtful, restrained, and effective filler injection has come.…”