A phenanthridin-6(<i>5H</i>)-one derivative and a lanostane-type triterpene with antibacterial properties from <i>Anonidium mannii</i> (Oliv). Engl. &amp; Diels (Annonaceae)

Ngangoue, Marcelle O.; Ngameni, Bathélémy; Ambassa, Pantaléon; Fru, Godloves; Wamba, Brice E. N.; Ombito, Japheth O.; Bojase, Gomotsang; Fotso, Ghislain Wabo; Kuete, Victor; Ngadjui, Bonaventure T.

doi:10.1080/14786419.2020.1758094

Cited by 8 publications

(1 citation statement)

References 24 publications

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“…Yasanuka et al, for example, noted differences among plant parts when examining the antibacterial properties of extracts created from the fruits, heartwoods, leaves, fruit peels, roots, stems and twigs of various Mexican medicinal plants [21]. Interestingly, several authors have observed that extracts prepared from different plant parts of the Annonaceae family using a variety of organic solvents showed apparent selective antimicrobial and antiparasitic activities [22][23][24]. As the inclusion and separate study of plants obtained from differing environments and times in search of efficacy would likely add substantially to workload, it may be wise to reference and mirror what plant parts were selected, and what methods were employed for procurement, in traditional medical practice.…”

Section: Three Key Considerations Regarding Methods In the Search Formentioning

confidence: 99%

Challenges and Considerations in the Preparation of Novel Antibiotic Phytochemicals

Eichelbaum

Abood

Acuña

et al. 2020

EJMP

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Drug-resistant pathogenic and opportunistic bacteria pose a global health threat. Plants, particularly those employed in traditional (folk) medicine, may provide a source of antimicrobials compounds possessing novel mechanisms of action with which to combat current and emerging infectious diseases. However, experimental designs in ethnobotanical investigations of this type are complicated by several factors. Among these are chemotype variations among plants and plant parts, and potential antagonistic, additive or synergistic effects between plant compounds. These efforts are further hindered by a lack of standardized applicable chemical extraction methods in the field, which makes assessment and comparison of experimental results difficult. This overview thus seeks to provide insight into these complicating factors, give a brief historical survey of ancient investigations into antibiotics, and identify some of the strengths and weaknesses of the various modern methods and techniques routinely employed in ethnobotanical antibiotic research.

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