“…Hundreds of neuronal signal transduction models have been developed to test the criticality of different chemical species. Several reviews of the models exist, some focus on just a few different models whereas others give an overview of more than hundred models (Brown et al, 1990 ; Neher, 1998 ; Hudmon and Schulman, 2002a , b ; Bi and Rubin, 2005 ; Holmes, 2005 ; Wörgötter and Porr, 2005 ; Ajay and Bhalla, 2006 ; Klipp and Liebermeister, 2006 ; Zou and Destexhe, 2007 ; Morrison et al, 2008 ; Ogasawara et al, 2008 ; Bhalla, 2009 ; Ogasawara and Kawato, 2009 ; Tanaka and Augustine, 2009 ; Urakubo et al, 2009 ; Castellani and Zironi, 2010 ; Gerkin et al, 2010 ; Graupner and Brunel, 2010 ; Hellgren Kotaleski and Blackwell, 2010 ; Manninen et al, 2010 ; Shouval et al, 2010 ). The models range from a simple models with just a single reversible reaction to very detailed models with several hundred reactions.…”