Over the past decade, scholarly attention has increasingly focused on what is known as the ‘refugee gap’, which refers to the great difficulty asylum seekers and refugees face in entering the labour market in the host country. This poses a grave threat of social and occupational marginalisation for this group and highlights the role of systemic factors in facilitating resilience outcomes. By adopting a systemic perspective, this research aims to provide a critical reflection on the key features that should be considered when designing and implementing effective career counselling interventions for asylum seekers and refugees. To this end, a systematic review of the international applied research published by October 2022 has been carried out, using the PRISMA model. The 20 selected publications are grouped according to three main career research strands that reflect the core aspects to be addressed within career interventions in order to assist asylum seekers and refugees in their life and career transition in the host country, namely (i) psychosocial resources, (ii) identity transformation processes, and (iii) lived experiences and meaning-making processes. The main findings of the studies are discussed by looking into common themes that emerge from the literature, namely challenges related to migration contexts, self-regulating personal resources and skills, and sense of self and identity in career transitions, as well as considerations on the design aspects of career counselling and research targeting As&R. Finally, some guidelines and directions for action are provided for the purpose of developing inclusive career counselling interventions for As&R.