A Phenomenon of Topical Protection Against Hyperergic Inflammation by a Preceding Local Inflammation

Abstract

65larks and venules, but relatively few had infiltrated the adjacent tissues.Summary.(1) The inflammatory reactions resulting from thermal injuries were compared in cortisone-treated animals with those in untreated controls. ( 2 ) Diapedesis, capillary hemorrhages and edema were quantitatively much less in the cortisone-treated animals. Hyperemia and leukocytic infiltration also were less in degree but the difference in these items was not so marked as in diapedesis, hemorrhages and edema. (3) There is acceptable evidence that the corticoid hormones increase the resistance of capillary walls. The authors believe that this effect reduces the degree of each of the features in the inflarnmatory reaction.

Effects of Salicylate on Prophylactic Counter-Irritation.

“…Local hyporeactivity at the site of irritation has been established (6,7,8,9). Ry altering or blocking the PCI mechanism, salicylates may allow a more rapid return to the initial reactivity.…”