A photodynamic therapy combined with topical 5-aminolevulinic acid and systemic hematoporphyrin derivative is more efficient but less phototoxic for cancer

Wang, Yu; Lin, Yong; Zhang, Huiguo; Zhu, Jing

doi:10.1007/s00432-015-2066-3

Cited by 40 publications

(34 citation statements)

References 21 publications

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“…[30][31][32][33] Photodynamic therapy using porphyrin derivatives, however, often results in prolonged systemic side effects, especially if the photosensitizing agent is injected. 34 This led to development of second-and third-generation photosensitizers with more specificity toward tumor cells while sparing normal cells.…”

Section: Discussionmentioning

confidence: 99%

“…51,52 Studies have shown that topical application of photosensitizing agents, such as in dermatologic applications, is also effective. 34 Fluid-filled balloons that distribute the light to the cavity walls have been studied to evenly distribute the therapeutic light throughout. 5 Recently, a few studies have also demonstrated the potential application of interstitial PDT applied via laser fibers for intra-tumor light delivery in non-resectable and recurrent glioblastomas.…”

Section: Discussionmentioning

confidence: 99%

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Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

et al. 2018

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This is the first study to our knowledge to demonstrate the photodynamic effect of AO in glioblastoma cells. These data support the need for further studies to characterize and evaluate whether this striking cytotoxic effect can be achieved in vivo. The combination of AO and exposure to white unfiltered light-emitting diode light may have potential future applications in management of glioblastoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

et al. 2018

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“…However, similar approaches have been poorly explored in the field of PDT. Few investigations have been published involving the combination of two PSs targeting different subcellular compartments, but the results are very promising [38][39][40][41][42][43][44][45][46]. Interestingly, most of these studies have involved the use of porphyrinic compounds.…”

Section: Combination Of Tmpyp With Other Photosensitizersmentioning

confidence: 99%

Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications

García-Sampedro

Tabero

Mahamed

et al. 2019

J. Porphyrins Phthalocyanines

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The cationic porphyrin meso-tetra(4-[Formula: see text]-methylpyridyl)porphine (TMPyP) has a high yield of singlet oxygen generation upon light activation and a strong affinity for DNA. These advantageous properties have turned it into a promising photosensitizer for use in photodynamic therapy (PDT). In this review, we have summarized the current state-of-the-art applications of TMPyP for the treatment of cancer as well as its implementation in antimicrobial PDT. The most relevant studies reporting its pharmacokinetics, subcellular localization, mechanism of action, tissue biodistribution and dosimetry are discussed. Combination strategies using TMPyP-PDT together with other photosensitizers and chemotherapeutic agents to achieve synergistic anti-tumor effects and reduce resistance to therapy are also explored. Finally, we have addressed emerging applications of this porphyrin, including nanoparticle-mediated delivery, controlled drug release, biosensing and G-quadruplex stabilization for tumor growth inhibition. Altogether, this work highlights the great potential and versatility that TMPyP can offer in different fields of biomedicine such us cancer treatment or antimicrobial therapy.

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“…Moreover, topical usage of antibiotic has many potential advantages over systematic use. At present, the benefits of topical antibiotic prophylaxis and treatment with various agents have been documented for multiple surgical disciplines, including ophthalmic, orthopaedic, neurological, urological and general surgeries …”

Section: Introductionmentioning

confidence: 99%

The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis

Wang

Long

et al. 2019

Int J Clin Pract

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Summary Objectives The purpose of this study was to conduct a systematic review and meta‐analysis in patients with local wound infection or infective risk, evaluating effects of topical gentamycin application on prophylaxis and treatment of wound infection. Methods Embase, the Cochrane Library, Pubmed, Medline (from Ovid) and three Chinese literature databases (CNKI, VIP and WANFANG) were searched. Randomised controlled studies (RCTs) and observational studies (OSs) that assessed the efficacy of topical gentamycin application on prophylaxis and treatment of local wound infection were included. The primary outcome was clinical efficacy. Secondary outcomes included duration of recovery time and length of hospital stay. Results Fifteen studies (1781 patients) met inclusion criteria. Twelve studies were RCTs and other three studies were OSs. Compared with non‐gentamycin group, topical gentamycin application had significantly higher rates of clinical efficacy (OR = 3.57, 95% CI 2.52‐5.07). In terms of duration of wound healing, it's taken shorter time in gentamycin group than non‐gentamycin group (OR = −4.94, 95% CI −8.37 to −1.51). However, the length of hospital stay had no significantly difference between the two groups (OR = −3.40, 95% CI −8.42 to 1.63). Subgroup analyses were conducted according to study design (RCTs or OSs), purpose and administration type. And the results showed that there were no significant difference of clinical efficacy in study design (P = 0.21, I2 = 35.4%), purpose (P = 0.32, I2 = 0%) and administration type subgroup (P = 0.74, I2 = 0%). However, topical gentamycin application had significantly shorter duration of wound healing in randomly controlled trials compared with observational studies, but had no difference in terms of administration type(P = 0.20, I2 = 38.6%). Conclusions Studies to date show that topical gentamycin application significantly increases the rate of clinical efficacy and decreases the duration of wound healing in patients with local wound infection or infective risk.

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A photodynamic therapy combined with topical 5-aminolevulinic acid and systemic hematoporphyrin derivative is more efficient but less phototoxic for cancer

Abstract: The combined PDT not only shows high cure rate for skin cancers but also decreases the dose of the pro-toxic HPD and significantly shortens the photosensitive period, from which the patients are able to benefit.

Cited by 40 publications

References 21 publications

Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications

The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis

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