A Physical Model of the Human Circulatory System for the Modeling, Control and Diagnostic of Cardiac Support Processes

Siewnicka, Alicja; Janiszowski, K.; Gawlikowski, M.

doi:10.1007/978-3-319-02294-9_104

Cited by 4 publications

References 14 publications

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Mechanical, Structural, and Chemical Analysis of Athrombogenic Multilayer Wall of Ventricular Assist Device Tested in Hydrodynamic Fatigue Tests

et al. 2016

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The purpose of the paper is to assess an impact of short‐ and long‐term operational load on continuity and composition of TiN/Au layers deposited on the polymer Bionate II that the pulsatile ventricular assist device Religa Heart Ext is made of. The additional objective is to determine mechanical properties of the TiN/Au layers deposited on the polymer. The physical model of circulatory system was built using the Windkessel model. The tests with the use of energy dispersive spectroscopy and scanning electron microscopy were made on surfaces of samples made of the Religa Heart Ext material examined in the fatigue tests. Mechanical properties of the TiN/Au coatings deposited on the polymer were measured in the nanoindentation test by comparison of the coated and the uncoated samples.

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Mechanical, Structural, and Chemical Analysis of Athrombogenic Multilayer Wall of Ventricular Assist Device Tested in Hydrodynamic Fatigue Tests

et al. 2016

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Recurrent Neural Networks in Prediction of Blood Flow in Hybrid-Digital Model of Cardiovascular System

Ślęzak,

Kopernik,

Major

2024

Lecture Notes in Bioengineering

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Switching the Left and the Right Hearts: A Novel Bi-ventricle Mechanical Support Strategy with Spared Native Single-Ventricle

Şişli,

Yıldırım,

Aka

et al. 2023

Ann Biomed Eng

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Mechanical circulatory support (MCS) is used as a bridge-to-heart transplantation for end-stage failing Fontan patients with single-ventricle (SV) circulation. Donor shortage and complexity of the single-ventricle circulation physiology demands novel circulatory support systems and alternative solutions. An out-of-the-box circulation concept in which the left and right ventricles are switched with each other inspired a novel bi-ventricle MCS configuration for the "failing" Fontan patients. In the proposed configuration, the systemic circulation is maintained by a conventional mechanical ventricle assist device while the venous circulation is delegated to the native SV. This approach spares the SV and puts it to a new use at the right-side providing the most needed venous flow pulsatility. To analyze its feasibility and performance, 8 realistic Fontan circulation scenarios have been studied via a multi-compartmental lumped parameter cardiovascular model (LPM). Model is developed specifically for simulating the SV circulation and validated against pulsatile mock-up flow loop measurements for the ideal (Fontan), failed (VD) and assisted Fontan (PVR-cmcs) scenarios. The proposed surgical configuration maintained the cardiac index (3-3.5 l/min/m 2 ) providing a normal mean systemic arterial pressure. For a failed SV with low ejection fraction (EF=26%), representing a typical systemic failure, proposed configuration introduced a venous/pulmonary pulsatility of ~28 mmHg and a drop of 2 mmHg in central venous pressure (CVP) with acceptable pulmonary artery pressures (17.5 mmHg). In the pulmonary vascular resistance (PVR) failure model, it provided approximately 5 mmHg drop in CVP with venous/pulmonary pulsatility reaching ~22 mmHg. For high PVR failure case with a healthy SV (EF = 44%) pulmonary hypertension is likely to occur, indicating a need for precise functional assessment of the failed-ventricle before it is considered for the proposed arrangement.Comprehensive in vitro and in silico results encourage this concept as an economical alternative to the conventional bi-ventricle MCS pending animal experiments.

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A Physical Model of the Human Circulatory System for the Modeling, Control and Diagnostic of Cardiac Support Processes

Cited by 4 publications

References 14 publications

Mechanical, Structural, and Chemical Analysis of Athrombogenic Multilayer Wall of Ventricular Assist Device Tested in Hydrodynamic Fatigue Tests

Mechanical, Structural, and Chemical Analysis of Athrombogenic Multilayer Wall of Ventricular Assist Device Tested in Hydrodynamic Fatigue Tests

Recurrent Neural Networks in Prediction of Blood Flow in Hybrid-Digital Model of Cardiovascular System

Switching the Left and the Right Hearts: A Novel Bi-ventricle Mechanical Support Strategy with Spared Native Single-Ventricle

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