A Phytochemical in the Edible Tamogi-take Mushroom (<i>Pleurotus cornucopiae</i>),<scp>D</scp>-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

Hagiwara, Shinji; Takahashi, Masayuki; Shen, Yangyang; Kaihou, Shinobu; Tomiyama, Takeshi; Yazawa, Michio; Tamai, Yasukatsu; Sin, Yoosu; Kazusaka, Akio; Terazawa, Minoru

doi:10.1271/bbb.69.1603

Cited by 62 publications

(39 citation statements)

References 17 publications

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“…Relatively high levels of linoleic acid, trehalose, and, particularly, of mannitol that are characteristic for S. subtomentosum might also be valuable considering renewed interests in (un)saturated fatty acids as modulators of lipid metabolism [25] and soluble saccharides as cryptobiotic substances [26] with a potential for treatment of serpinopathies [27] and Huntingtons disease [28]. Mannitol, one of the main phytochemicals of S. subtomentosum, has been claimed to protect against oxidation by hydroxyl radicals, confer protection against the development of colon cancer [29], inhibit ACE activity, and lower the blood pressure of hypersensitive rats [30].…”

Section: Results Andmentioning

confidence: 99%

Chemical Constituents of Stereum subtomentosum and Two Other Birch‐Associated Basidiomycetes: An Interspecies Comparative Study

Hybelbauerová

Sejbal

Dračínský

et al. 2008

Chemistry & Biodiversity

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Metabolites of the wood-rotting fungus Stereum subtomentosum Pouzar (Basidiomycetes, order Russulales, family Stereaceae) occurring on birch (Betula pendula Roth) trees were phytochemically investigated for the first time. Three main metabolite chemotypes present in MeOH extracts of the fruit bodies, viz. steroids, fatty acids, and water-soluble sugars, were fractionated, isolated, and identified by 1D/2D NMR-spectroscopic analyses, NMR data comparisons, and chemical correlations combined with GC/MS experiments. Thirteen compounds including two 5 alpha,8 alpha-epidioxy steroids, alpha,alpha'-trehalose, D-arabinitol, D-mannitol, and saturated/unsaturated fatty acids, were identified. Differences among S. subtomentosum and two other birch-associated fungal species, Trametes versicolor (L.: Fr.) Pilát, and Piptoporus betulinus (Bull.: Fr.) P. Karst (Basidiomycetes, order Polyporales, family Polyporaceae) were evaluated as regards the richness and abundance relationships in metabolite profiling.

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Section: Results Andmentioning

confidence: 99%

Chemical Constituents of Stereum subtomentosum and Two Other Birch‐Associated Basidiomycetes: An Interspecies Comparative Study

Hybelbauerová

Sejbal

Dračínský

et al. 2008

Chemistry & Biodiversity

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“…7) Eritadenin isolated from Lentinula edodes has been reported to lower serum cholesterol levels. [9][10][11][12] More recently, hypotensive and hypoglycemic effects have been reported for the aqueous extracts of Pleurotus cornucopiae 13) and methanol-extracts of Hericum erinaceum, 14) respectively. It is also reported that polysaccharide from Inonotus obliquus has immune stimulation activity.…”

mentioning

confidence: 99%

In Vitro and in Vivo Anti-oxidant Activity of Hot Water Extract of Basidiomycetes-X, Newly Identified Edible Fungus

Watanabe

Nakajima

Konishi

2008

Biological & Pharmaceutical Bulletin

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“…Chemical modification and spectral analysis of reaction product were useful in establishing the structure of Compound 5. The compounds isolated from the leaves of P. crassipes were identified as ß-sitosterol C 29 H 50 O (1) (Lee et al 2003), ursolic acid (2) C 30 H 48 O 3 (Seebacher et al 2003), methyl chlorogenate C 17 H 20 O 9 (3) (Lee et al 2010), ethyl chlorogenate C 18 H 22 O 9 (4) (Lee et al 2010), rutin C 27 H 30 O 16 (5) (Lallemand & Duteil 1977, Bello et al 2011) and mannitol C 6 H 12 O 6 (6) (Hagiwara et al 2005). Quercetin C 15 H 10 O 7 (5a), the hydrolyzed product of rutin, was also identified (Lallemand & Duteil 1977).…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents and antimycobacterial studies of the leaf extracts of Pavetta crassipes K. Schum

Ibekwe¹,

Boshoff²,

Randle³

et al. 2018

Trop. Plant Res.

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Six known compounds; β-sitosterol, ursolic acid, methyl chlorogenate, ethyl chlorogenate, rutin and mannitol were isolated from the leaf extracts of Pavetta crassipes (Rubiaceae), a Nigerian medicinal plant used in the indigenous treatment of tuberculosis. Separation and isolation of the compounds were achieved by chromatographic techniques and the structures of isolated compounds were established by spectroscopic and chemical methods. The isolated compounds were screened for antimycobacterial activities against Mycobacterium tuberculosis H 37 Rv employing the green fluorescence protein reporter microplate assay and the broth microdilution method. Ursolic acid, methyl chlorogenate and ethyl chlorogenate were found moderately active in the broth microdilution assay with MICs of 200, 100 and 50 µg/ml, respectively while methyl chlorogenate and ethyl chlorogenate were active in the protein reporter microplate assay with MICs of 200 and 100 µg ml -1 , respectively. The presence of antimycobacterial terpenoids and quinate esters in leaves of Pavetta crassipes provides scientific evidence for the ethnomedicinal use of the plant as a traditional anti-tuberculosis remedy.

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A Phytochemical in the Edible Tamogi-take Mushroom (Pleurotus cornucopiae),D-Mannitol, Inhibits ACE Activity and Lowers the Blood Pressure of Spontaneously Hypertensive Rats

Cited by 62 publications

References 17 publications

Chemical Constituents of Stereum subtomentosum and Two Other Birch‐Associated Basidiomycetes: An Interspecies Comparative Study

Chemical Constituents of Stereum subtomentosum and Two Other Birch‐Associated Basidiomycetes: An Interspecies Comparative Study

In Vitro and in Vivo Anti-oxidant Activity of Hot Water Extract of Basidiomycetes-X, Newly Identified Edible Fungus

Chemical constituents and antimycobacterial studies of the leaf extracts of Pavetta crassipes K. Schum

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