“…However, the piglet offers a better model of the human brain, with similar cortical grey-white differentiation, gyral pattern and physiologic responses to TBI in humans [27,28]. Outcomes assessed in previous swine TBI intervention studies have included mean arterial pressure [29,30,31], intracranial pressure [30,31,32], cerebral blood flow [29,30,31,32], brain tissue oxygen tension [29], cerebral metabolic rate of oxygen [31], immunohistochemistry [29,30,31], histopathology [30,31,33] and lesion volume by magnetic resonance imaging [29,32]. Simple functional testing has been performed in swine TBI studies [32,34] with the use of a veterinary coma scale, similar to the Glasgow Coma Scale [35] used in humans.…”