Pruritus is a common manifestation of many dermatologic conditions. Previous research demonstrated that pruritus negatively impacts quality of life. However, the impact of pruritus is often underappreciated in dermatology and nondermatology settings, alike. We hypothesized that many of the harmful effects of pruritus that are most concerning to patients are not sufficiently addressed in the review literature read by clinicians who treat pruritus. We sought to characterize the most common patient-reported concerns related to pruritus and determine whether there was concordance with clinical review articles.This systematic review was designed to identify all review articles and qualitative or mixed methods studies pertaining to the impact of pruritus on quality of life. We searched MEDLINE, Embase, and Cochrane Library from its beginning to February 1, 2015, for a combination of "prurit*" and "itch*" (*wildcard character) and "quality of life," "QOL," "patient burden," "patient reported outcome," "patient report," "patient perspective," and "patient centered." Studies were excluded based on the title, abstract, or both if there was no indication they investigated or discussed pruritus, its impact on quality of life, or both. Therapeutic trials, animal studies, and foreign-language articles were excluded.Two reviewers, P. D. and R. K., performed data extraction and any differences were resolved by discussion. Articles were classified as original research studies if they used qualitative or mixed methods to assess primary, patient-reported data. Thematic analysis was performed in NVivo 10 (QSR International, Burlington, MA). Items were ranked based on frequency of use as a measure of how often they were addressed.