A pilot study comparing mechanical properties of tissue-engineered cartilages and various endogenous cartilages

Pappa, Andrew K.; Soleimani, Sajjad; Caballero, Montserrat; Halevi, Alexandra E.; Aalst, John A. van

doi:10.1016/j.clinbiomech.2017.10.010

Cited by 7 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors reported that the elastic modulus increased with increasing age in all the native cartilage samples, except the preauricular tags, and it was the highest in the costal cartilage (361 ± 372 kPa), followed by microtia, preauricular appendages, normal conchal cartilage (31.8 ± 18 kPa), and the TE pellet. 26 A similar pattern was observed in the stressrelaxation rates. The highest value was seen in costal cartilage (64.7 kPa/s), followed by microtia, preauricular, and conchal cartilage (15.1 kPa/s).…”

Section: Compressive Propertiessupporting

confidence: 72%

“…All the native samples were compared with tissue-engineered (TE) cartilage generated from umbilical cord MSCs to identify the best candidate for reconstruction purposes. The authors reported that the elastic modulus increased with increasing age in all the native cartilage samples, except the preauricular tags, and it was the highest in the costal cartilage (361±372 kPa), followed by microtia, preauricular appendages, normal conchal cartilage (31.8±18 kPa), and the TE pellet 26 . A similar pattern was observed in the stress-relaxation rates.…”

Section: Tissue Engineeringmentioning

confidence: 60%

“…Auricular cartilage has viscoelastic properties and is primarily composed of collagen and elastin fibers that encompass a proteoglycan gel. 26,27 This structural composition allows the cartilage to retain water, which translates into an elastic response to load. Elastin is the major contributor to the intrinsic mechanical properties of the auricular cartilage.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…The bulk moduli and Young's moduli were higher than rat/rabbit but lower than pig/cow. 31 Lastly, Pappa et al 26 utilized atomic force microscopy (MFP-3DBio; Asylum Research, Santa Barbara, CA) and compression testing (Bose ElectroForce 3100, Framingham, MA) to determine the elastic moduli and stress-relaxation rates of cartilage samples from various ages of patients from the normal conchal bowl, microtia ears, and preauricular tags. Costal cartilage was also characterized because it is used in autologous reconstruction.…”

Section: Compressive Propertiesmentioning

confidence: 99%

“…The TE pellet exhibited the lowest value (7.6 ± 1.1 kPa/s). 26 The geometric stiffness of the whole ear is another mechanical parameter reported in the literature. Zopf et al 34 used an MTS Alliance RT/30 testing machine, equipped with a 500 N load cell, to apply load at a constant displacement rate of 10 mm/min to the entire, intact ear.…”

Section: Compressive Propertiesmentioning

confidence: 99%

See 4 more Smart Citations

Tissue Engineering Auricular Cartilage: A Review of Auricular Cartilage Characteristics and Current Techniques for Auricular Reconstruction

Khan,

Zaki,

Brown

et al. 2024

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Microtia and anotia are congenital auricular anomalies that negatively impact the psychosocial development of those affected. Because auricular cartilage is a type of elastic cartilage that lacks regenerative capacity, any notable defect in its structure requires a surgical approach to reconstructing the auricle. While there are several reconstructive options available between alloplastic and prosthetic implants, autologous rib cartilage grafts remain the most commonly used treatment modality. Still, this widely used technique is accompanied by significant patient discomfort in a young child and carries additional risks secondary to the traumatic process of rib cartilage extraction, such as pneumothorax and chest wall deformities, and the final esthetic results may not be ideal. To circumvent these limitations, tissue engineering approaches have been used to create a realistic-looking ear that mirrors the complex anatomy of the normal ear. This article reviews the biochemical and biomechanical properties of human auricular cartilage as they relate to design criteria. In addition, a variety of cell sources, biocompatible scaffolds, scaffold-free techniques, and mechanical and biological stimuli are discussed. This review aims to identify knowledge gaps in the literature related to auricular cartilage characteristics and make recommendations to drive the field of auricular tissue engineering.

show abstract

Section: Compressive Propertiessupporting

confidence: 72%

Section: Tissue Engineeringmentioning

confidence: 60%

Section: Mechanical Propertiesmentioning

confidence: 99%

Section: Compressive Propertiesmentioning

confidence: 99%

Section: Compressive Propertiesmentioning

confidence: 99%

See 3 more Smart Citations