A pilot study of acupuncture at pain acupoints for cervical cancer pain

Meng, Fanfeng; Feng, Yanhong

doi:10.1097/md.0000000000013736

Cited by 10 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Generally, the course of cancer is accompanied by chronic pain, which is a serious problem for cancer patients and remarkably affects their quality of life (QOL) [ 7 ]. Therefore, except for the therapies such as surgery, chemotherapy, and radiotherapy to control the proliferation and metastasis of cancer [ 8 , 9 ], pain relief may be beneficial for improving the patient's QOL while also supplementing cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway

Jiang¹,

Li²,

Qian³

et al. 2022

Pain Research and Management

View full text Add to dashboard Cite

Background. The role of ketamine as an adjuvant for morphine in the treatment of cancer pain and immune functions has been confirmed. This study aimed to explore the role of morphine and ketamine on cancer pain and T cells of patients with cervical cancer (CC). Methods. T cells were isolated from peripheral blood mononuclear cells (PBMC) of CC patients by positive selection using anti-CD3 beads. The isolated T cells were assigned into three groups: the control group, the morphine group, and the morphine + ketamine (Mor + Ket) group. The percentages of CD4+ and CD8+ were analyzed by flow cytometry. The levels of interferon (IFN)-γ, interleukin (IL)-2, and IL-17 and the corresponding mRNA expression in vitro were determined using ELISA and qRT-PCR, respectively. Western blotting was used for detection of JAK3/STAT5 pathway-related proteins after naltrexone treatment in vitro. Afterwards, all the patients were further divided into the morphine group and the Mor + Ket group in accordance with the principles of the randomized and double-blind method to assess pain intensity. Results. Our in vivo results showed that drug combinations relieved cancer pain more effectively than morphine intervention. The in vitro results demonstrated that the combination of morphine and ketamine may decrease CD4+ percentage, CD4+/CD8+ ratio, and the levels of IFN-γ, IL-2, and IL-17 via the JAK3/STAT5 pathway. Conclusions. Our finding indicated that morphine-ketamine combination could improve cancer pain and repress immune function via the JAK3/STAT5 pathway in the progression of CC.

show abstract

Section: Introductionmentioning

confidence: 99%

Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway

Jiang¹,

Li²,

Qian³

et al. 2022

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…Pain is a symptom present in advanced stage cancer and its intensity varies according to the location, type of treatment and degree of evolution (Costa & Chaves, 2012). For this study, five articles related to cancer pain were selected and analysed, among which three performed randomised clinical trials, one carried out a pilot study with a retrospective design and one produced an observational study (Bao, Li, et al, 2018; Bao, Seidman, et al, 2018; Bao, Zhi, et al, 2018; Hershman et al, 2018; Kim & Lee, 2018; Meng & Feng, 2018; Ruela et al, 2018). In addition, the population selected for the randomised clinical trials ranged from 27 to 226 participants, while 592 people participated in the observational study (Bao, Li, et al, 2018; Bao, Seidman, et al, 2018; Bao, Zhi, et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The study that applied auricular acupuncture (Ruela et al, 2018) selected 31 participants and used ShenMen and Zero Point. While some studies (Kim & Lee, 2018; Meng & Feng, 2018) selected 27 and 64 participants, respectively, for body acupuncture, and used the CV12, ST25, LI4, LR3, PC06, ST36, SP6 acupoints and additionally 0–3 Ashi points. Sessions lasted an average of 30 min, with Kim and Lee (2018) leaving the needles fixed with skin tape (needles measuring .18 × 1.3 × 1.5 mm) for 48–72 h and the patients were instructed to press the needle sites with their hands twice a day.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture techniques and acupoints used in individuals under chemotherapy or radiotherapy treatment of cancer: A systematic review

Sousa

Mattos²,

Marcon³

et al. 2023

Journal of Clinical Nursing

View full text Add to dashboard Cite

Aims and ObjectivesTo describe the main acupuncture techniques and parameters that have been used in the most varied symptoms of different types of cancer.BackgroundClinical evidence about the potential effectiveness of acupuncture and related therapies to control signs and symptoms associated with cancer or its treatment has been in several studies. Currently, there is already evidence of the use of acupuncture for the treatment of nausea and vomiting, fatigue, dry mouth, anxiety, depression, insomnia and pain. However, many studies lack firm rights or reproducible guidelines for treatment.DesignThis study performs a systematic review of clinical trials related to the topic, based on the PRISMA protocol. Thus, a search was carried out in the Scopus, Pubmed and Web of Science databases, covering studies since January 2007.MethodsStructured and organised according to PICO standards, using keywords (“cancer” OR “malignant tumour” OR “chemotherapy” OR “radiotherapy”) AND (“acupuncture” OR “electroacupuncture”) AND (“pain” OR “nausea” OR “vomit” OR “fatigue” OR “xerostomia” OR “insomnia” OR “depression” OR “neuropathy”).ResultsAfter the selection and evaluation phase, 23 studies were included and analysed.ConclusionBased on this analysis, it is concluded that acupuncture is safe and there is evidence of the reduction of gastrointestinal symptoms, chemotherapy‐induced peripheral neuropathy, pain, dry mouth, fatigue, insomnia, and improvement of cognitive capacity.Relevance to clinical practiceAcupuncture treatments could act by minimising the side effects of conventional treatments and reducing symptoms induced by tumours.No Patient or Public ContributionThe patients had no direct involvement with the study in question.

show abstract

“…Estimations based on trial of acupuncture for cervical cancer pain [ 17 ] of 64 patients with changing NRS from baseline of −4.2 in acupuncture group and −2.2 in control group ( P < .01), indicated that a sample of 168 patients (equally divided into control and treatment groups) would suffice to achieve 90% statistical power for detecting a significant greater decrease of NRS in TENS group than in control group at a two-sided significance level of 0.05. For these calculations, patients undergoing TENS were assumed to themselves experience a decrease of 2.2 in pain scores (compared with their baseline pain scores) due to a placebo effect.…”

Section: Methodsmentioning

confidence: 99%

Multicenter, randomized, double-blind, controlled trial of transcutaneous electrical nerve stimulation for pancreatic cancer related pain

Tan

Lin

et al. 2021

Medicine

View full text Add to dashboard Cite

Background: Up to 80% of patients with pancreatic cancer experience abdominal and back pain. Although pharmacologic medications provide some relief, many report inadequate analgesia and adverse effects. Transcutaneous electrical nerve stimulation (TENS) is a non-invasive physical modality and had been widely applied for pain relieving, yet no study has investigated the effectiveness of TENS for pain in pancreatic cancer. Methods: Eligible patients were randomly assigned in a 1:1 ratio to TENS group or control group. The primary outcome was percentage change of numerous rating scale (NRS) after treatment. Secondary outcomes included percentage change of analgesic medication consumption and effect on constipation and poor appetite. Results: One hundred seventy-one patients were recruited (84 to control group and 87 to TENS group). NRS in TENS group has been largely decreased 77.9% right after treatment and 27.1% in 2 hours, before applying any analgesic medication, while that in control group was slightly downregulated right after treatment but gave a trend to increase at 1, 2, and 3 hours. When comparing both groups, pain was significantly well controlled without analgesic medication supplement in TENS group at 0 hour (difference in mean percent change in NRS = 50.0 [95% CI, 50–51.4], P < .01) and 3 hours (difference in mean percent change in NRS = 134.0 [95% CI, 130.0–142.7], P < .01) after treatment, and this analgesic effect last to 3 weeks after treatment cycle (difference in mean percent change in NRS = 22.5 [95% CI, 17.6–27.3], P < .01) without increase of analgesic medication consumption. Conclusions: TENS reduces pain without increase analgesic medication consumption in patients with pancreatic cancer pain. It provides an alternative therapy for pain in pancreatic cancer. Clinical Trial Registration: This study was registered at ClinicalTrials.gov, identifier NCT03331055.

show abstract

A pilot study of acupuncture at pain acupoints for cervical cancer pain

Cited by 10 publications

References 28 publications

Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway

Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway

Acupuncture techniques and acupoints used in individuals under chemotherapy or radiotherapy treatment of cancer: A systematic review

Multicenter, randomized, double-blind, controlled trial of transcutaneous electrical nerve stimulation for pancreatic cancer related pain

Contact Info

Product

Resources

About