A Pilot Study of Concomitant Radiation and Chemotherapy in Patients with Locally Advanced Head and Neck Cancer

Tomio, L.; Zorat, Pier Luigi; Paccagnella, Adriano; Segati, Romana; Loreggian, L.; Lora, O.; Friso, Maria Luisa; Chiarion-Sileni, Vanna; Favaretto, Adolfo; Fede, Antonella; Andreoli, C; Francini, Francesco; Sala, O.; Fiorentino, Mario V.; Calzavara, F.

doi:10.1097/00000421-199306000-00014

Cited by 6 publications

(2 citation statements)

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“…Other approaches to this devastating symptom are clearly needed, particularly as the treatment becomes more aggressive, leading to higher rates of acute toxicities. [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] They should be examined in carefully designed studies using an objective validated scoring instrument. In the meantime, new technology in radiation treatment such as intensity-modulated radiotherapy might enable further reduction of the treated mucosal volume without compromising the chance of tumor control.…”

Section: Discussionmentioning

confidence: 99%

Prophylaxis of Radiation-Associated Mucositis in Conventionally Treated Patients With Head and Neck Cancer: A Double-Blind, Phase III, Randomized, Controlled Trial Evaluating the Clinical Efficacy of an Antimicrobial Lozenge Using a Validated Mucositis Scoring System

El-Sayed

Nabid

Shelley

et al. 2002

JCO

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This study was conducted on the basis of a pilot study that demonstrated the BCoG lozenge to be tolerable and microbiologically efficacious. A validated mucositis scoring system was used. However, in this group of patients treated with conventional radiotherapy, the lozenge did not impact significantly on the severity of mucositis. Whether such a lozenge would be beneficial in treatment situations where rate of severe mucositis is higher (ie, in patients treated with unconventional fractionation or with concomitant chemotherapy) is unknown.

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Section: Discussionmentioning

confidence: 99%

Prophylaxis of Radiation-Associated Mucositis in Conventionally Treated Patients With Head and Neck Cancer: A Double-Blind, Phase III, Randomized, Controlled Trial Evaluating the Clinical Efficacy of an Antimicrobial Lozenge Using a Validated Mucositis Scoring System

El-Sayed

Nabid

Shelley

et al. 2002

JCO

View full text Add to dashboard Cite

show abstract

“…Protocols developed to preserve the larynx, pharynx, or tongue with chemotherapy and irradiation rather than extirpative surgery have become increasingly popular over the last decade. [41][42][43][44] Whereas management of cancers at most sites with adjuvant chemotherapy has not improved cure rates, recent reports [45][46][47] indicate that the addition of adjuvant chemotherapy may offer more effective treatment for nasopharyngeal carcinoma.…”

Section: Treatmentmentioning

confidence: 99%