A Pilot Study of Glycosylated Hemoglobin Levels in Periodontitis Cases and Healthy Controls

Wolff, Ryan; Wolff, Larry F.; Michalowicz, Bryan S.

doi:10.1902/jop.2009.080664

Cited by 52 publications

(61 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results support the earlier fi nding where chronic periodontitis was found to be associated with a slight elevation in glycosylated haemoglobin (Figure-3). 13 Further the results are also found to be consistent with earlier findings where chronic periodontitis was reported to be associated with elevated blood glucose in adults without diabetes and may increase one's risk for type-2 diabetes, 16 as the group of non-Diabetic patients suffering from Periodontitis was signifi cantly differed from the control (normal health) group (Figure-4). There are many studies reporting association between periodontal disease and diabetes and is now well established fact that periodontal disease is more prevalent and severe in persons with diabetes than in non-diabetic patients.…”

Section: Discussionsupporting

confidence: 90%

“…9 Similar studies have evidenced increased serum Immunoglobulin-G, Immunoglobulin-A and Immunoglobulin-M in periodontitis patients, 10,11 while others reported no significant differences in serum immunoglobulin levels between periodontitis patients and healthy individuals. 12,13 The changes observed in immune response may be the cause or the effect of periodontal disease in diabetic patients. The increased incidence of periodontitis and gingival infl ammation in patients showing hyperglycaemia suggests that the contribution of alteration in immune response leading to pathogenesis of periodontitis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Chaurasia

Kulshrestha²,

Pooja

et al. 2014

Asian J Med Sci

View full text Add to dashboard Cite

Objective: Diabetics are more susceptible to the infections than the non-diabetics (healthy) one, suggesting that the immunologic capability may be unbalanced in diabetics. Periodontitis is associated with alterations in immune responses in both diabetic and non-diabetic subjects. Till date various attempts has been taken to monitor host immunological response of diabetic individuals. Therefore the need to study the local immune response in infl amed gingival showing Periodontitis is apparent. Since till date there are no well documented and signifi cant baseline studies are available on the functional capacities of the lymphoid cells present in gingiva of the periodontitis patients, a study to check the level of immunoglobulin was investigated. Methodology: A study was carried out where HbA1c, Random Blood Sugar and Serum IgA level were assessed in 60 patients from the OPD of RCDSR. 15 patients each belonging to the four groups diabetic with periodontitis, diabetic without periodontitis, nondiabetic with periodontitis and non-diabetic without periodontitis (control) were analysed for the quantitative estimation of Serum Immunoglobulin A by Turbidometric Immunoassay and HbA1c was done by using Nyco card Reader. Result: The data thus obtained were compared with the level of immunoglobulin found in clinically healthy gingival of the control group. The levels of IgA were found to be high in group 'A' (Diabetic patients suffering from Periodontitis) group 'B' (Diabetic patients not suffering from Periodontitis) and group 'C' (Non-diabetic patients suffering from Periodontitis) but the values are not differing statistically from each other. But, the values of all these groups are statistically highly differed from the value obtained against the normal/healthy controlled group 'D'. Conclusion: In our study it can be concluded that there was positive co-relation between the two parameters: elevated HbA1c and Immunoglobulin level with periodontitis. This co-relates to the possibility of an underlying immuno-infl ammatory abnormality to be the cause for the elevated level of immunoglobulin in our patients with elevated sugar level.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Chaurasia

Kulshrestha²,

Pooja

et al. 2014

Asian J Med Sci

View full text Add to dashboard Cite

show abstract

“…We also observed a positive association between the levels of HbA1c and number of sites associated with loss of attachment of more than 3 mm. Our result was in contrast to the results obtained by Wolff et al 4 Difference in the severity of the periodontitis cases included in the present study and the study of Wolff et al 4 In the study, approximately 5,600 subjects were evaluated without periodontal pockets of more than or equal to 4 mm at the initial baseline time. For the period of 5 years, the relative risk for the occurrence of periodontal pocket of equal to more than 4 mm was assessed in the individuals in which HbA1c levels were more than 6.5% in comparison to the baseline levels.…”

Section: Resultscontrasting

confidence: 99%

“…Since HbA1c is based on the mean life cycle time of red blood cells, glycemic control over the past 4 to 12 weeks is reflected in terms of it. 4 Literature quotes numerous studies in which higher severity of periodontal diseases is seen in diabetic subjects in comparison to nondiabetic subjects; there is a paucity of studies targeting only the nondiabetic individuals. 5 Hence, we planned the present study to evaluate the levels of HbA1c in nondiabetic patients with periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Levels of Glycosylated Hemoglobin in Patients with Periodontal Pathologies: A Comparative Study

Wahi

Tripathi

Wahi

et al. 2017

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

Introduction One of the potential sources for the occurrence of various systemic pathologies, such as cardiovascular diseases, cerebrovascular diseases, and respiratory diseases is periodontitis. Testing of glycosylated hemoglobin (HbA) is a highly standardized procedure and is becoming increasingly popular these days due to its cost-effectiveness and ease of use. Literature quotes numerous studies associating the periodontal diseases with various hemoglobin markers in diabetic and nondiabetic patients. Hence, we planned the present study to assess the levels of HbA in patients with periodontitis among nondiabetic patients. Materials and methods For the present study, a total of 50 nondiabetic subjects who reported to the department with the chief complaint of periodontitis were included. Another set of 50 nondiabetic individuals were included in the present study of comparable age in whom no periodontitis was detected clinically. Clinical examination and radiographic evaluation was performed for the selection of the cases for the study group. The patients were sent to the laboratory after the clinical examination, for the testing of HbA. Testing of the hemoglobin A1c (HbA1c) levels of all the subjects and controls was performed and values were noted and evaluated. Results Nonsignificant results were obtained while comparing the mean HbA1c concentrations among the study group and the control group. Nonsignificant results were obtained while comparing the mean HbA1c levels among males and females. While comparing the mean HbA1c levels between the study group and the control group divided on the basis of body mass index, nonsignificant results were obtained. Conclusion In nondiabetic subjects, no significant correlation could be observed between periodontitis and HbA1c levels. Clinical significance The HbA1c cannot be used as a reliable maker for differentiation of patients with periodontal pathologies from patients free of periodontal pathologies. How to cite this article Wahi S, Tripathi A, Wahi S, Mishra VD, Singh AP, Sinha N. Assessment of Levels of Glycosylated Hemoglobin in Patients with Periodontal Pathologies: A Comparative Study. J Contemp Dent Pract 2017;18(6):506-509.

show abstract

“…Wolff y col., demostraron que el predominio de EP es mayor en el sexo masculino con un IMC superior a 30 y DM tipo 2 (68%) con un promedio de 50,9 años de edad mientras que en el sexo femenino, la princi-pal manifestación fue el sangrado gingival (32%); en la presente investigación la EP fue mayor (bolsas de 4 -5 mm 83,53%) y el sangrado gingival (97,65%) con una edad promedio de 48 años en pacientes con obesidad y DM tipo 2; ambos estudios difi eren ya que la muestra utilizada por Wolff sólo fue de 59 pacientes en total (30).…”

Section: Discussionunclassified

Enfermedad periodontal en pacientes diabéticos tipo 2 con y sin obesidad en Lima, Perú

Carrera¹,

Contreras²,

Ventura³

et al. 2016

Rev Estomatol Herediana.

View full text Add to dashboard Cite

Objetivos: Determinar si la enfermedad periodontal afecta más a pacientes diabéticos tipo 2 con obesidad que a los pacientes sin obesidad. Material y métodos: La población estuvo conformado por 170 pacientes con diagnósticode Diabetes Mellitus (DM) tipo 2; fueron divididos en dos grupos 85 diabéticos obesos y 85 diabéticos no obesos: el grupo obesos fue de 55 mujeres y 30 hombres mientras que el grupo sin obesidad fue de 37 mujeresy 48 hombres. Se utilizó el Índice Periodontal Comunitario Modifi cado y la fi cha de registro de datos aprobados por la OMS, la evaluación clínica se realizó tomando en cuenta, profundidad de las bolsas y la presencia de furcadental. Resultados: De los 85 pacientes con obesidad, el 83,53% presentó bolsas periodontales de 4-5 mm y el 16,47% presentó bolsas ≥ 6 mm, mientras que en el grupo sin obesidad el 90,59% presentó bolsas de 4-5 mm, el 7,06% presentó bolsas ≥ 6 mm y el 2,35% no presentó bolsas. Conclusión: No hay diferencias en los signos de enfermedad periodontal en pacientes con diabetes mellitus tipo 2 con obesidad y sin obesidad.

show abstract

A Pilot Study of Glycosylated Hemoglobin Levels in Periodontitis Cases and Healthy Controls

Cited by 52 publications

References 22 publications

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Assessment of Levels of Glycosylated Hemoglobin in Patients with Periodontal Pathologies: A Comparative Study

Enfermedad periodontal en pacientes diabéticos tipo 2 con y sin obesidad en Lima, Perú

Contact Info

Product

Resources

About