A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma

Druzgal, Colleen; Chen, Zhong; Yeh, Ning T.; Thomas, Giovana R.; Ondrey, Frank G.; Duffey, Dianne C.; Vilela, Ronald Jason; Ende, Kevin; McCullagh, Linda; Rudy, Susan F.; Muir, Christine; Herscher, Laurie L.; Morris, John C.; Albert, Paul S.; Waes, Carter Van

doi:10.1002/hed.20246

Cited by 87 publications

(80 citation statements)

References 32 publications

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“…This appeared to represent a process of ''recovery'' towards pre-treatment levels, taking place as soon as chemo-irradiation was stopped. We could find only two relevant studies in the literature [9,10]; both were limited to sVEGF, and their conclusions were in disagreement with ours. However, we suggest that both of them might have inadvertently missed the process of increment in sVEGF levels during that interval, because of their different study design.…”

Section: Discussioncontrasting

confidence: 76%

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Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal carcinoma patients

et al. 2008

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Section: Discussioncontrasting

confidence: 76%

“…In that study, 18/25 patients were treated with three cycles of chemotherapy. Each cycle involved five days of continuous infusion of paclitaxel, and was administered every three weeks along the course of irradiation [10].…”

mentioning

confidence: 99%

Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal carcinoma patients

et al. 2008

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“…In addition we demonstrated a higher level of expression in many of the angiogenic factors in both the tumour tissue and the associated nodal tissue, compared with tissue from the healthy control group, which is in accordance with previous studies where angiogenic factor levels of MMP-9 (24), HGF, VEGF (21,25) and IL-8 (22) were increased in patients with HNSCC compared with the control group (21). In contrast to the angiogenesis-related proteins, which increased with tumour progression, angiogenin and TIMP1 were found to decrease with disease progression.…”

Section: Discussionsupporting

confidence: 92%

“…In addition we have shown that there is increased expression of some of these factors in the normal mucosa adjacent to the tumour compared with both the metastatic nodal tissue and uvula control tissue, suggesting that the processes may be occurring in a wider area than just the main tumour mass, potentially predisposing the patient to recurrence or the development of a second primary tumour supporting the 'field of cancerization' hypothesis. The angiogenic growth factors VEGF, IL-8, bFGF, HGF are commonly found to be overexpressed in HNSCC in lysates (8) and systemically (21,22). In the current study 32 of the 40 angiogenesis-related proteins analysed had an increasing expression in the tumour tissue with advancement of the tumour stage.…”

Section: Discussionmentioning

confidence: 99%

Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression

Korampalli

Green²,

Greenman

et al. 2011

Int J Oncol

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Abstract. The expression of angiogenesis-related proteins was determined in laryngeal tumour tissue, associated tumour involved lymph nodes, apparently normal mucosa and control tissue and were related to tumour stage. Both laryngeal tumour tissue and associated metastatic nodes were obtained from seven patients undergoing surgical resection; in four cases apparently normal mucosa was also dissected from the tumour specimen margins. Control uvula mucosa was obtained from five healthy volunteers undergoing uvulopalatopharyngoplasty. The relative expression of 55 angiogenesis-related proteins was determined in tissue lysates using a Proteome Profiler human angiogenesis array kit. The level of 32/55 angiogenesis-related proteins was higher in tumour tissue compared with controls. Furthermore, in these tumour biopsies higher levels of proteins were associated with increasing tumour stage. A similar trend was seen for 29/32 of these proteins in the nodal tissue. In T4 stage tumour tissue samples, 29/55 angiogenensis-related proteins were more highly expressed compared with the adjacent normal mucosa from the same patient, and this decreased to 8 proteins in tumour tissue from the T1 stage patients. In contrast, the expression of 23 angiogenesis-related proteins in metastatic lymph node tissue from T4 stage patients was lower compared with that found in the normal mucosa adjacent to the tumour. In conclusion, this study has identified a number of factors involved in angiogenesis that are likely to contribute to the growth and metastasis of laryngeal tumours. Furthermore, a number of factors were also substantially altered in metastatic deposits compared with the primary tumour mass or adjacent normal tissue. This study requires confirmatory analysis of the selected key factors in a larger cohort of patients.

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“…However, in accordance with the present findings, no positive correlation was observed between tissue TIMP-1 positivity or serum TIMP-1 levels and disease stage or tumour grade. Druzgal et al (29) reported that the serum levels of IL-6, IL-8, hepatocyte growth factor and VEGF were increased in patients with HNSCC as compared to the normal control group. However, no association was observed between IL-8 levels and tumour stage in the present study or between tumour and metastatic nodes.…”

Section: Discussionmentioning

confidence: 99%

Expression of angiogenic growth factors in laryngeal carcinoma

Korampalli

Stafford

2013

Molecular and Clinical Oncology

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Abstract. Over 2,200 cases of carcinoma of the larynx are diagnosed in the UK annually, with an overall 5-year survival rate of 67%. Angiogenesis is vital for the growth and metastasis of solid tumours and the expression of key angiogenesis-related proteins has been shown to be of prognostic significance. In this study we reported the expression of key angiogenesis-related factors, selected from a pilot array study, in a cohort of laryngeal tumours and associated metastatic lymph nodes. Forty patients diagnosed with squamous cell carcinoma of the larynx were recruited. Tissue specimens were obtained intra-operatively, prior to chemo-and/or radiotherapy, from the tumours and secondary lymph nodes. The patient group comprised 32 men and 8 women with a mean age of 68 years (range, 51-89 years). The relative expression of the angiogenesis-related proteins angiogenin, interleukin (IL)-8, tissue inhibitor of metalloproteinases-1 (TIMP-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-basic and insulin-like growth factor binding protein 3 (IGFBP3) was determined in the tissue lysates by ELISA. The expression of angiogenin was higher in early-stage compared with late-stage tumours (P=0.034) and the expression of IGFBP3 was higher in tumours compared with the metastatic lymph nodes (P=0.016). No statistically significant differences were recorded for VEGF, FGF, TIMP-1 or IL-8 between tumour stages or primary tumours and lymph nodes. To the best of our knowledge, this study was the first to investigate multiple angiogenic factors in the lysates of laryngeal carcinomas and metastatic nodes and identified angiogenin and IGFBP3 as factors possibly involved in tumour progression. A greater understanding of their function may offer novel prognostic and/or therapeutic options.

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A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma

Cited by 87 publications

References 32 publications

Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal carcinoma patients

Daily low-dose/continuous capecitabine combined with neo-adjuvant irradiation reduces VEGF and PDGF-BB levels in rectal carcinoma patients

Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression

Expression of angiogenic growth factors in laryngeal carcinoma

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