A Pilot Study of Prognostic Value of Metastatic Lymph Node Count and Size in Patients with Different Stages of Gastric Carcinoma

Abstract

Background The correlation between the preoperative lymph node count (LNC) on multidetector computed tomography (MDCT) and the prognosis of gastric carcinoma (GC) remains to be defined. This research aims to evaluate the prognostic value of LNC on MDCT in GC patients based on tumor-node-metastasis (TNM) staging, using different size criteria for counting. Methods The clinical data of 126 patients with gastric adenocarcinoma undergoing gastrectomy were retrospectively analyzed. Lymph nodes greater than 8mm and 5mm on MDCT were counted and recorded. The prognostic implications of LNC on MDCT for patient survival were analyzed according to different size criteria for counting and tumor TNM staging. Results When 8mm was used as the counting criterion, LNC on MDCT had no significant effect on the overall survival (OS) of the entire cohort. In addition, the OS of T1–T2 GC patients with LNC on MDCT ≥1 was significantly worse than that of patients with LNC on MDCT <1. When 5mm was used as the counting criterion, LNC on MDCT was found to be significantly associated with the OS of the entire cohort. In the subgroup analysis, patients with relatively advanced (T3-T4, N+ and III) GC with LNC on MDCT >7 showed a significantly worse OS than those with LNC on MDCT ≤7. LNC on MDCT >7 with 5mm as the counting criterion and Stage III were independent risk factors for adverse prognosis. Conclusion The prognostic value of LNC on MDCT based on different size criteria varies in patients with different stages of GC. LNC of a smaller size (5mm) on MDCT may be a prognostic factor for patients with relatively advanced GC.

Sistem Pakar Deteksi Hemangioma pada Batita menggunakan Metode Hybrid

“…Hal tersebut biasanya terjadi karena pertumbuhan dari pembuluh dara yang terjadi secara berlebihan (proliferasi). Perubahan warna tersebut terjadi disebabkan oleh pembuluh darah yang berada di permukaan kuluiit semakin melebar dan tak jarang juga memiliki warna keunguan jika kondisi tersebut terjadi di lapisan dalam pada pembuluh darah [6]. Kondisi tersebut disebut dengan hemangioma.…”

Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI

“…The treatment response is evaluated according to the response evaluation criteria in solid tumors (RECIST), which mainly assesses the changes of tumor size on computed tomography (CT) [ 1 , 2 ]. Nonetheless, the size of tumor changes lagging than biological and molecular levels [ 3 , 4 ]. Therefore, explorations of reliable surrogate markers that can indicate treatment response are warranted.…”