A Pilot Study of Proinflammatory Cytokines and Fatigue in Women With Breast Cancer During Chemotherapy

Raudonis, Barbara M.; Kelley, Ingrid H.; Rowe, Nancy; Ellis, Jenny

doi:10.1097/ncc.0000000000000406

Cited by 13 publications

(18 citation statements)

References 29 publications

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“…While the other studies included patients with different types of cancer, having patients with one type of cancer is thought to be the reason for this high score in the present study. Also, the literature indicates that patients with breast cancer have the highest level of fatigue compared to other cancer populations and it is thought that this may lead to this high score as well (5,24,25). The current validation study also provided evidence for the criterion validity of the CFS in Turkish.…”

Section: Discussionsupporting

confidence: 51%

Cross-cultural adaptation, reliability, and validity of the Turkish version of the Cancer Fatigue Scale in patients with breast cancer

Şahın¹,

Huri²,

Aran³

et al. 2018

Turk J Med Sci

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Background/aim: The Cancer Fatigue Scale (CFS) was developed to evaluate the severity of fatigue in patients with breast cancer. The aim of this study is to translate and culturally adapt a Turkish version and investigate the validity and reliability of the CFS in Turkish patients with fatigue symptoms. Materials and methods: Eighty participants completed the Turkish version of the CFS for breast cancer and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire ″Core 30″ (EORTC QLQ-C30). Test-retest reliability was evaluated by repeating the CFS with a 7-day interval. Results: The CFS demonstrated high test-retest reliability (ICC = 0.95) and good internal consistency (Cronbach′s alpha = 0.74) for all domains. The Kaiser-Meyer-Olkin measure of sampling adequacy was found to be 0.819, which is considered to be satisfactory (>0.5). Correlations between domains of CFS physical and EORTC physical (r: 0.77), CFS cognitive and EORTC cognitive (r: 0.70), and CFS physical and EORTC fatigue (r: 0.80) were found to be significant. Conclusion: The Turkish version of the CFS is a reliable and valid instrument to assess physical, effective, and cognitive dimensions of fatigue. The CFS may be used to evaluate the severity of fatigue in Turkish-speaking breast cancer patients.

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Section: Discussionsupporting

confidence: 51%

Cross-cultural adaptation, reliability, and validity of the Turkish version of the Cancer Fatigue Scale in patients with breast cancer

Şahın¹,

Huri²,

Aran³

et al. 2018

Turk J Med Sci

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“…It is proven that the inflammation disorder drives the pathology in early stages of the disease, and a significant role in the progress of the disease is played by mitochondrial dysfunction, induced by oxidative damage, which leads to the reduced activity of mtDNA and mitochondrial complexes [164]. However, there is a great variability in patients’ cytokine levels and degree of fatigue during their treatment trajectories [165]. The hypothesis that genetic differences in pro-inflammatory cytokines could influence this phenomenon is currently accepted.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

“…The hypothesis that genetic differences in pro-inflammatory cytokines could influence this phenomenon is currently accepted. Although a Genetic Risk Index was developed to predict a high risk of fatigue in women, there is no systemic explanation of the variability in CRF, and additional research is needed to identify CRF genetic variants [165,166].…”

Section: Conclusion and Discussionmentioning

confidence: 99%

A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis

Yang

Chu

Gao

et al. 2019

Cells

160

123

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Many cancer patients suffer from severe fatigue when treated with chemotherapy or radiotherapy; however, the etiology and pathogenesis of this kind of fatigue remains unknown. Fatigue is associated with cancer itself, as well as adjuvant therapies and can persist for a long time. Cancer patients present a high degree of fatigue, which dramatically affects the quality of their everyday life. There are various clinical research studies and reviews that aimed to explore the mechanisms of cancer-related fatigue (CRF). However, there are certain limitations in these studies: For example, some studies have only blood biochemical texts without histopathological examination, and there has been insufficient systemic evaluation of the dynamic changes in relevant indexes. Thus, we present this narrative review to summarize previous studies on CRF and explore promising research directions. Plenty of evidence suggests a possible association between CRF and physiological dysfunction, including skeletal muscular and mitochondrial dysfunction, peripheral immune activation and inflammation dysfunction, as well as central nervous system (CNS) disorder. Mitochondrial DNA (mtDNA), mitochondrial structure, oxidative pressure, and some active factors such as ATP play significant roles that lead to the induction of CRF. Meanwhile, several pro-inflammatory and anti-inflammatory cytokines in the peripheral system, even in the CNS, significantly contribute to the occurrence of CRF. Moreover, CNS function disorders, such as neuropeptide, neurotransmitter, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction, tend to amplify the sense of fatigue in cancer patients through various signaling pathways. There have been few accurate animal models established to further explore the molecular mechanisms of CRF due to different types of cancer, adjuvant therapy schedules, living environments, and physical status. It is imperative to develop appropriate animal models that can mimic human CRF and to explore additional mechanisms using histopathological and biochemical methods. Therefore, the main purpose of this review is to analyze the possible pathogenesis of CRF and recommend future research that will clarify CRF pathogenesis and facilitate the formulation of new treatment options.

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“…TNF induces fatigue in patients with metastatic cancer [85]. Further, women with breast cancer experience increases of fatigue and TNF levels during chemotherapy [86]. In pediatric obstructive sleep apnea patients, TNF levels increase, and are tightly related to sleepiness; plasma TNF levels, and sleepiness in these patients decrease after surgery [87] and are also associated with single nucleotide polymorphisms in the TNF gene [88].…”

Section: Linking Tnf To Human Sleepmentioning

confidence: 99%

Tumor necrosis factor alpha in sleep regulation

Rockstrom

Chen

Taishi

et al. 2018

Sleep Medicine Reviews

101

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This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and describes how TNF medications influence sleep/wake activity. Substantial evidence from healthy young animals indicates acute enhancement or inhibition of endogenous brain TNF respectively promotes and inhibits sleep. In contrast, the role of TNF in sleep in most human studies involves pathological conditions associated with chronic elevations of systemic TNF and disrupted sleep. Normalization of TNF levels in such patients improves sleep. A few studies involving normal healthy humans and their TNF levels and sleep are consistent with the animal studies but are necessarily more limited in scope. TNF can act on established sleep regulatory circuits to promote sleep and on the cortex within small networks, such as cortical columns, to induce sleep-like states. TNF affects multiple synaptic functions, e.g., its role in synaptic scaling is firmly established. The TNF-plasticity actions, like its role in sleep, can be local network events suggesting that sleep and plasticity share biochemical regulatory mechanisms and thus may be inseparable from each other. We conclude that TNF is involved in sleep regulation acting within an extensive tightly orchestrated biochemical network to niche-adapt sleep in health and disease.

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A Pilot Study of Proinflammatory Cytokines and Fatigue in Women With Breast Cancer During Chemotherapy

Abstract: These findings highlight the importance of symptom assessments including fatigue at each clinic visit and individualized interventions throughout the cancer trajectory.

Cited by 13 publications

References 29 publications

Cross-cultural adaptation, reliability, and validity of the Turkish version of the Cancer Fatigue Scale in patients with breast cancer

Cross-cultural adaptation, reliability, and validity of the Turkish version of the Cancer Fatigue Scale in patients with breast cancer

A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis

Tumor necrosis factor alpha in sleep regulation

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