RLIP76 (RALBP1) is a glutathione-conjugate transporter that is a critical component of clathrin-coated pit-mediated endocytosis, as well as in stress responses. In cultured cells, it provides protection from stressors including heat, oxidant chemicals, chemotherapeutic agents, UV irradiation, and X-irradiation. Here, we show marked reduction in glutathione conjugate transport capacity and stepwise increase in radiation sensitivity associated with heterozygous or homozygous loss of the RLIP76 gene in mice. Survival after radiation in homozygous knockout animals was significantly shorter than either the heterozygous knockouts or the wild type. Delivery of recombinant RLIP76 to mice lacking RLIP76 via a liposomal delivery system rescued radiation sensitivity. Furthermore, treatment of wild-type mice with RLIP76-containing liposomes conferred resistance to radiation. These findings suggest that inhibiting RLIP76 could be used for sensitization to radiation during cancer therapy and that RLIP76 liposomes could be radioprotective agents useful for treatment of iatrogenic or catastrophic radiation poisoning. (Cancer Res 2005; 65(14): 6022-8)

These findings highlight the importance of symptom assessments including fatigue at each clinic visit and individualized interventions throughout the cancer trajectory.

The study presented here explores the influences of selected social and social psychological factors that are associated with perceived caregiver burden in a sample of 263 primary caregivers of the elderly in Allahabad City in northern India. The results indicate that although male caregivers' perceived burden depends only on the size of the role overload, female caregivers' perceived burden depends on the interrelationship between the size of the role overload and adherence to Asian cultural norms. Implications of the findings for social work are discussed.

Mid-expiratory flow (FEF(25-75)) may be more informative than FEV1 in studies of acute lung function changes in children with asthma. Further study of the effects of varied environmental conditions on lower airway function of children is needed to optimize exercise experiences for urban children with asthma.

IN the last six years an unusual cancer affecting children in Africa (Burkitt, 1958) has come to the attention of the scientific community. This cancer is particularly noteworthy because of its high incidence in African children (the commonest childhood cancer in Africa) and its peculiar geographic distribution on that continent. It is characterized by an unusual anatomic distribution; the jaws being involved in the majority of cases and a nearly universal sparing of the peripheral lymph nodes. The African lymphoma syndrome is significant within the context of the total cancer problem in that the epidemiology is highly suggestive of viral etiology. Support for this concept is given by the age distribution, apparent lack of racial predilection, and geographical distribution which is related to altitude, temperature and humidity (Burkitt, 1962).A study of the prevalence and distribution of the Burkitt lymphoma outside Africa has not yet been reported. Considering the similarity of geographic distribution between the lymphoma in Africa and tropical vector-born viral diseases on that continent, and considering further that for the most part these same vectorborn viral diseases are endemic to the tropical areas of Central America, this area seemed most likely to contain information about the prevalence and distribution of this entity in the Western hemisphere. This study was initiated to gather information about the Burkitt lymphoma on this hemisphere.The present study was conducted in two parts. The first, a safari by dug-out canoe into the tropical jungles of Darien, Panama, searching clinical evidence of the tumor, and the second part, a search through the histopathologic collection at