A Pilot Study on Anticancer Activities of Chinese Leek

Abstract

CL extract inhibited cancer cell growth and induced apoptosis in vitro. Oral administration of CL extract significantly reduced lung metastases in the present animal model.

Anticancer Activities of Oldenlandia diffusa

“…In a previous study, we demonstrated that Chinese leek displayed anticancer activities in vitro and in vivo. 5 In the present study, we demonstrated that the herbal extract of Oldenlandia diffusa has minimal cytotoxicity to normal pancreatic cells. Furthermore, our animal study is consistent with previous mouse studies in which a high LD 50 of the herbal extract was noticed (i.e., 88-123 g/kg by intraperitoneal administration).…”

“…2,3 Traditional Chinese herbal medicine has a history of more than 5000 years. 4,5 Both ancient experience and modern studies have demonstrated that herbal medicine could be an effective remedy for cancer treatment and to improve the outcome of chemotherapy. A unique feature of the herbal remedies is the relatively low adverse effects.…”

Allium tuberosum aqueous extract had curative effects on malignant melanoma in C57BL/6 mice

“…Thus, thiosulfinates inhibited cell proliferation in vitro by activating apoptotic pathways in colon, prostate and human cancer cells, as well as in sarcoma murine cells [8,9,10]; tested in vivo they increased life spans of mice inoculated with sarcoma-180 cancer cells [10]. Likewise, Chitinase like 36 kD protein, isolated from chives exerted some cytotoxic effect in vitro on breast cancer cells [12]. Similarly, fresh AT phosphate-buffered saline extract inhibited growth of murine and human cancer cell lines in vitro [11].…”

“…Few studies have been done about AT effects on cancer models, most of them tested in vitro effects of thiosulfinates purified from chives [8,9,10], others used fresh aqueous buffered extract [11] or purified protein [12]. Thus, thiosulfinates inhibited cell proliferation in vitro by activating apoptotic pathways in colon, prostate and human cancer cells, as well as in sarcoma murine cells [8,9,10]; tested in vivo they increased life spans of mice inoculated with sarcoma-180 cancer cells [10].…”

In VitroAnticancer Activities ofLeonurus heterophyllusSweet (ChineseMotherwort Herb)

“…Many edible and medicinal plants described in the classic Chinese Materia Medica provide a potential resource for the research and development of chemopreventive agents of cancer (Han, 1999). Preliminary studies conducted on Chinese leek (Allium tuberosum Rottler), a common vegetable, have shown that the oral administration of Chinese leek extract was effective against B16-F10 melanoma lung metastases in C57BL mice (Shao et al, 2001). The efficacy of a prescription called Dang Gui Lu Hui Wan, which consists of 11 Chinese herbs, has been demonstrated for the treatment of chronic myelocytic leukemia (Han, 1999).…”