A pilot study on pediatric mononucleosis presenting with abscess

Levi, Jessica M.; Nassif, Samih J.; Shetty, Kishore; McKee-Cole, Katherine; Barth, Patrick

doi:10.1016/j.amjoto.2020.102716

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In a study of patients with severe IM, peritonsillar abscesses were not only reported as a complication, but were noted to be bilateral in 25 % of patients, which is significantly higher than the reported frequency in patients without IM [6] . Moreover, intratonsillar abscesses, which are rarely reported in the literature, have also been reported in cases of severe IM [3] . Streptococcus pyogenes , which is known to cause suppurative infections of the tonsils, has not been frequently isolated in these IM related tonsillar abscesses [6] .…”

Section: Discussionmentioning

confidence: 99%

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A case of bilateral peritonsillar abscesses as a complication of acute mononucleosis

Gomez Urena,

Sheehy,

Krastev

2023

IDCases

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Section: Discussionmentioning

confidence: 99%

“…Tonsillar or peritonsillar abscesses seem to be a potential complication of EBV infection that has been rarely described in the literature [3] . In 1998, Burstin et al reported a case of bilateral peritonsillar abscesses in a patient with mononucleosis receiving steroids [4] .…”

Section: Discussionmentioning

confidence: 99%

A case of bilateral peritonsillar abscesses as a complication of acute mononucleosis

Gomez Urena,

Sheehy,

Krastev

2023

IDCases

View full text Add to dashboard Cite

Infectious Mononucleosis: An Updated Review

Leung

Lam

Barankin³

2024

CPR

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Background: Infectious mononucleosis is common among adolescents and young adults. Although the majority of cases resolve spontaneously, life-threatening manifestations, and complications have been recognised. Objective: The purpose of this article is to familiarize clinicians with the clinical manifestations, evaluation, diagnosis, and management of infectious mononucleosis. Methods: A search was conducted in October 2022 in PubMed Clinical Queries using the key terms "infectious mononucleosis" OR “Epstein-Barr virus” OR “EBV”. The search strategy included all clinical trials, observational studies, and reviews published within the past 10 years. Only papers published in the English literature were included in this review. The information retrieved from the aforementioned search was used in the compilation of the present article. Results: Infectious mononucleosis, caused by Epstein-Barr virus, most commonly affects adolescents and adults aged 15 to 24 years. Epstein-Barr virus is transmitted primarily in saliva. Infectious mononucleosis is characterized by a triad of fever, tonsillar pharyngitis, and lymphadenopathy. Fatigue may be profound but tends to resolve within three months. Periorbital and/or palpebral edema, typically bilateral, occurs in one-third of patients. Splenomegaly and hepatomegaly occur in approximately 50% and 10% of cases, respectively. A skin rash, which is usually widely scattered, erythematous, and maculopapular, occurs in approximately 10 to 45% of cases. Peripheral blood leukocytosis is observed in most patients; lymphocytes make up at least 50% of the white blood cell differential count. Atypical lymphocytes constitute more than 10% of the total lymphocyte count. The classic test for infectious mononucleosis is the demonstration of heterophile antibodies. The monospot test is the most widely used method to detect the serum heterophile antibodies of infectious mononucleosis. When confirmation of the diagnosis of infectious mononucleosis is required in patients with mononucleosis-like illness and a negative mono-spot test, serologic testing for antibodies to viral capsid antigens is recommended. Infectious mononucleosis is a risk factor for chronic fatigue syndrome. Spontaneous splenic rupture occurs in 0.1 to 0.5% of patients with infectious mononucleosis and is potentially life-threatening. Treatment is mainly supportive. Reduction of activity and bed rest as tolerated are recommended. Patients should be advised to avoid contact sports or strenuous exercise for 8 weeks or while splenomegaly is still present. Most patients have an uneventful recovery. Conclusion: Infectious mononucleosis is generally a benign and self-limited disease. Prompt diagnosis is essential to avoid unnecessary investigations and treatments and to minimize complications. Splenic rupture is the most feared complication. As avoiding exposure to EBV is almost impossible, the most effective way to prevent EBV infection and infectious mononucleosis is the development of an effective, safe, and affordable EBV vaccine that can confer life-long immunity.

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A pilot study on pediatric mononucleosis presenting with abscess

Cited by 2 publications

References 11 publications

A case of bilateral peritonsillar abscesses as a complication of acute mononucleosis

A case of bilateral peritonsillar abscesses as a complication of acute mononucleosis

Infectious Mononucleosis: An Updated Review

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