A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff

Oza, Noriko; Eguchi, Yuichiro; Mizuta, Toshihiko; Ishibashi, Eriko; Kitajima, Yoichiro; Horie, H.; Ushirogawa, Michiko; Tsuzura, Takeko; Nakashita, Shunya; Takahashi, Kazuhiro; Kawaguchi, Yasunori; Oda, Yoshimasa; Iwakiri, Ryuichi; Ozaki, Iwata; Eguchi, Takahisa; Ono, Naofumi; Fujimoto, Kazuma

doi:10.1007/s00535-009-0115-x

Cited by 87 publications

(96 citation statements)

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“…In addition, the most important modification for an individual with ASH is the cessation of alcohol consumption and improved dietary habits. Considerable recent work has reviewed the previous studies, strategies, and recommendations of lifestyle modification as treatment for steatohepatitis (59,97,130,143,156), and new human trials continue to be reported describing successful treatment of liver pathology utilizing lifestyle modification paradigms (89,152,164). Managing body weight is likely the best overall method in the treatment of NASH.…”

Section: Lifestyle Modificationmentioning

confidence: 99%

Mitochondria and Redox Signaling in Steatohepatitis

Morris

Rector

Thyfault

et al. 2011

Antioxidants & Redox Signaling

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Alcoholic and nonalcoholic fatty liver diseases are potentially pathological conditions that can progress to steatohepatitis, fibrosis, and cirrhosis. These conditions affect millions of people throughout the world in part through poor lifestyle choices of excess alcohol consumption, overnutrition, and lack of regular physical activity. Abnormal mitochondrial and cellular redox homeostasis has been documented in steatohepatitis and results in alterations of multiple redox-sensitive signaling cascades. Ultimately, these changes in signaling lead to altered enzyme function and transcriptional activities of proteins critical to mitochondrial and cellular function. In this article, we review the current hypotheses linking mitochondrial redox state to the overall pathophysiology of alcoholic and nonalcoholic steatohepatitis and briefly discuss the current therapeutic options under investigation. Antioxid. Redox Signal. 15, 485-504.

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Section: Lifestyle Modificationmentioning

confidence: 99%

Mitochondria and Redox Signaling in Steatohepatitis

Morris

Rector

Thyfault

et al. 2011

Antioxidants & Redox Signaling

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“…Previous studies have reported a beneficial effect of a recommended diet combined with an increase in physical activity on the progression of NAFLD [6] . One study showed that a 7% to 10% weight reduction through intensive lifestyle intervention would lead to improvements in biochemical and histological features of nonalcoholic steatohepatitis (NASH) [7] .…”

Section: Introductionmentioning

confidence: 97%

Lifestyle intervention in non-alcoholic fatty liver disease in Chengyang District, Qingdao, China

Sun¹,

Song²,

Jiang³

et al. 2012

WJH

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AIM:To evaluate the effect of a 6 and 12 mo lifestyle modification intervention in nonalcoholic fatty liver diseases (NAFLD) in Chengyang District of Qingdao. METHODS:Participants with NAFLD who had resided in Chengyang District for more than 5 years were enrolled in this study. After the 6 and 12 mo lifestyle modification intervention based on physical activity, nutrition and behavior therapy, parameters such as body weight, body mass index (BMI), waist circumference, serum alanine aminotransferase (ALT), aspartate aminotransferase values, serum cholesterol, triglycerides, fasting glucose, fasting insulin and visceral fat area (VFA), the liver-spleen ratio and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated and compared between participants with and without the intervention. RESULTS:Seven hundred and twenty-four participants were assigned to the lifestyle intervention group (LS) and 363 participants were assigned to the control group (CON). After the intervention, body weights in the LS group were significantly decreased compared to those in the CON group at 6 mo (11.59% ± 4.7% vs 0.4% ± 0.2%, P = 0.001) and at 12 mo (12.73% ± 5.6% vs 0.9% ± 0.3%, P = 0.001). Compared with the CON group, BMI was more decreased in the LS group after 6 and 12 mo (P = 0.043 and P = 0.032). Waist circumference was more reduced in the LS group than in CON (P = 0.031 and P = 0.017). After the 6 and 12 mo intervention, ALT decreased significantly in the LS group (P = 0.003 and P = 0.002). After 6 and 12 mo, the metabolic syndrome rate had decreased more in the LS group compared with the CON group (P = 0.026 and P = 0.017). After 12 mo, the HOMA-IR score decreased more obviously in the LS group (P = 0.041); this result also appeared in the VFA after 12 mo in the LS group (P = 0.035). CONCLUSION:Lifestyle intervention was effective in improving NAFLD in both 6 and 12 mo interventions. This intervention offered a practical approach for treating a large number of NAFLD patients in the Chengyang District of Qingdao.

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“…At the end of six months, the interference of hepatic enzymes and the ratio of liver to spleen improved in these people. 90 Determining the therapeutic effect of weight loss in the clinical trial has two restrictions as follow: the first restriction is due to the little number of samples in the study and the second one is to determine the effect of weight loss on liver histology because liver biopsy is performed in the studies due to ethical considerations. The liver biopsy is essential for evaluating the effect of weight loss on hepatic steatosis.…”

Section: Weight Lossmentioning

confidence: 99%