A plausible involvement of GABAA/benzodiazepine receptor in the anxiolytic-like effect of ethyl acetate fraction and quercetin isolated from Ricinus communis Linn. leaves in mice

Murade, Vaishali D.; Waghmare, Amit; Pakhare, Deepali S.; Dichayal, Sonali; Patil, Rajesh B.; Wanjari, Manish; Gurav, Shailendra; Hase, D. P.

doi:10.1016/j.phyplu.2021.100041

Cited by 12 publications

(7 citation statements)

References 92 publications

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“…While PG, HT, and HTN significantly (p<0.01, p<0.05, and p<0.01, respectively) decreased time spent and closed arm entries than chronic stress animals ( Fig 6C and 6D ). As compared to HT, HTN treatment resulted in significantly (p<0.05) more time spent in the open arm and less time spent in the closed arm, suggesting the superior therapeutic efficacy of HTN [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

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Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin

et al. 2022

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The present study intends to formulate, characterize and appraise the phospholipid-based nanovesicular system for enhanced delivery of Hesperetin (HT). The quality by design (QbD) approach was employed to prepare Hesperetin naturosomes (HTN) using the solvent evaporation technique and assessed for physicochemical and pharmacological attributes. The FTIR, DSC, and PXRD studies confirmed the successful formation of a vesicular drug-phospholipid complex, while photomicroscopy, SEM, and TEM analysis revealed the morphology of HTN. The functional attributes substantially enhanced the HT’s aqueous solubility, drug release, and membrane permeation. The aqueous solubility of HTN was ~10-fold more than that of pure HT. Likewise, the in-vitro dissolution data of HTN showed better competence in releasing the HT (>93%) than the pure HT (~64%) or the physical mixture (~74%). Furthermore, HTN significantly altered HT permeation (>53%) when compared to pure HT (23%) or the physical mixture (28%). The current study showed that naturosomes are a promising way to improve the solubility in water, bioavailability, and therapeutic effectiveness of drugs.

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Section: Resultsmentioning

confidence: 99%

“…Elevated plus-maze (EPM) apparatus. The EPM apparatus was employed according to the protocol described by Murade et al (2021) [11]. Rats who underwent chronic stress were alienated into five groups (n = 6); Group I: treated with vehicle; Group II: Chronic stress; Group III: Chronic stress +PG (100 mg/kg, p.o.…”

Section: In-vivo Biological Activitymentioning

confidence: 99%

Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin

et al. 2022

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“…The comparions between groups were conducted using one-way ANOVA and Dunnett's t-test. Multiple comparisons with control were adopted to determine the statistical significance ( p < 0.05) between groups [ 7 , 11 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of “Murcchana samskara” on therapeutic efficacy of Bhallatakadi Ghrita

Wayal

Barke²,

Nigade³

et al. 2022

Journal of Ayurveda and Integrative Medicine

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“…The solutions of standards (caffeic acid and β-sitosterol) were prepared in CH 3 OH. Calibration curve of standard samples were prepared by using different concentrations and concentrations of the phytoconstituents in various fractions were determined by Autochro-3000 data acquisition system [28] .…”

Section: Gc-ms and Rp-hplc Studymentioning

confidence: 99%

Reversed-Phase High-Performance Liquid Chromatography Quantification, Gas Chromatography-Mass Spectrometry Study and In Vitro Antioxidant Potential of Clerodendrum serratum Linn. Roots

Hase¹,

Waghmare²,

Kadam³

et al. 2022

IJPS

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Hase et al.: Antioxidant Potential of Clerodendrum serratum Linn. RootsThe present study was aimed to identify and to quantify the phytoconstituents by gas chromatography-mass spectrometry, reversed phase-high performance liquid chromatography techniques and further to evaluate their in vitro antioxidant potential. In this study, the roots of Clerodendrum serratum Linn. was subjected to soxhlet extraction using n-hexane, chloroform, ethyl acetate and ethanol solvents and the obtained extracts were analyzed by gas chromatography-mass spectrometry technique. The caffeic acid and beta-sitosterol were quantified from the extracts using reversed phase high performance liquid chromatography technique. Total phenolic and flavonoid content were determined using established methods viz. Folin-Ciocalteu and aluminium chloride colorimetric assay. Antioxidant potential was assessed using in vitro methods such as 2, 2-diphenyl-1-picrylhydrazyl scavenging activity; ferric reducing ability of plasma assay and total antioxidant activity. The gas chromatography-mass spectrometry analysis revealed the presence of 48 compounds, out of which 41 compounds were identified and among them caffeic acid and beta-sitosterol were quantified using reversed phase high performance liquid chromatography technique. The abundance of phenolic and flavonoid content was found in ethyl acetate and residual aqueous fractions. The half maximal inhibitory concentration values of 2, 2-diphenyl-1-picrylhydrazyl assay was found to be 1.24, 3.36, 10.61 μg/ml for the residual aqueous fraction, ethyl acetate and chloroform fractions respectively and the total antioxidant activity was found to be 960±0.25, 766±0.14 and 816.6±0.28 μg/mg for the chloroform, ethyl acetate and residual aqueous fractions respectively showing strong antioxidant activity. The ferric reducing ability of plasma assay showed strongest reducing power for residual aqueous fraction and ethyl acetate fractions. The results showed that the residual aqueous fraction and ethyl acetate fractions had strong antioxidant potential. It may be concluded from the results that the Clerodendrum serratum Linn. roots possesses significant antioxidant potential may be due to presence of potent phenolic and flavonoid compounds and these finding supports the traditional use of plant to treat the oxidative stress and related disorders.

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A plausible involvement of GABAA/benzodiazepine receptor in the anxiolytic-like effect of ethyl acetate fraction and quercetin isolated from Ricinus communis Linn. leaves in mice

Cited by 12 publications

References 92 publications

Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin

Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin

Effect of “Murcchana samskara” on therapeutic efficacy of Bhallatakadi Ghrita

Reversed-Phase High-Performance Liquid Chromatography Quantification, Gas Chromatography-Mass Spectrometry Study and In Vitro Antioxidant Potential of Clerodendrum serratum Linn. Roots

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